Structured evidence table for Vitamin K2 Bone Density Systematic Review, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Vitamin K2 Bone Density Systematic Review | Currently, large-scale direct comparative statistics are still insufficient, but existing evidence supports that Asian dietary patterns are more beneficial to skeletal health. | 3 | Zhang Tianzhu (2026) | The Gut-Bone Axis and Skeletal Health: Regulatory Mechanisms and Therapeutic Applications of Plant-Derived Bioactive Compounds |
| Vitamin K2 Bone Density Systematic Review | Despite substantial progress, the field still faces several bottlenecks, including unclear strain-specific and compound-specific mechanisms, insufficient large-scale clinical evidence, low bioavailability of phytochemicals, and lack of standardized intervention regimens. | 3 | Zhang Tianzhu (2026) | The Gut-Bone Axis and Skeletal Health: Regulatory Mechanisms and Therapeutic Applications of Plant-Derived Bioactive Compounds |
| Vitamin K2 Bone Density Systematic Review | By integrating mechanistic insights, preclinical evidence, clinical advances, and translational prospects, this review aims to enrich the current understanding of the gut–bone axis and provide a theoretical foundation and practical guidance for subsequent research and clinical development of plant-based therapies against osteoporosis and other metabolic bone diseases. | 3 | Zhang Tianzhu (2026) | The Gut-Bone Axis and Skeletal Health: Regulatory Mechanisms and Therapeutic Applications of Plant-Derived Bioactive Compounds |
| Vitamin K2 Bone Density Systematic Review | 1 2 The gut–bone axis refers to the functional connection between the gut and the skeletal system, established through a complex bidirectional communication network. | 3 | Zhang Tianzhu (2026) | The Gut-Bone Axis and Skeletal Health: Regulatory Mechanisms and Therapeutic Applications of Plant-Derived Bioactive Compounds |
| Vitamin K2 Bone Density Systematic Review | In OVX mice, MK-4 treatment significantly increased alkaline phosphatase activity and bone volume, improved bone mineral density (BMD), and reduced undercarboxylated osteocalcin (ucOC) []. | 4 | Jecan Alexandru (2026) | Discrepancy Between Biological Activity and Functional Fracture Healing Following Vitamin K2 Supplementation in an Ovariectomized Rat Model of Osteoporosis |
| Vitamin K2 Bone Density Systematic Review | Long-term MK-7 supplementation in OVX rats prevented trabecular bone loss and significantly improved bone strength [,]. | 4 | Jecan Alexandru (2026) | Discrepancy Between Biological Activity and Functional Fracture Healing Following Vitamin K2 Supplementation in an Ovariectomized Rat Model of Osteoporosis |
| Vitamin K2 Bone Density Systematic Review | 7 8 Despite this evidence supporting improved bone status, the effects of MK-4 and MK-7 on osteoporotic fracture healing remain less well documented. | 4 | Jecan Alexandru (2026) | Discrepancy Between Biological Activity and Functional Fracture Healing Following Vitamin K2 Supplementation in an Ovariectomized Rat Model of Osteoporosis |
| Vitamin K2 Bone Density Systematic Review | 1 2 3 2 4 5 6 Osteoporosis and postmenopausal estrogen deficiency are well known to impair bone strength and fracture repair. | 4 | Jecan Alexandru (2026) | Discrepancy Between Biological Activity and Functional Fracture Healing Following Vitamin K2 Supplementation in an Ovariectomized Rat Model of Osteoporosis |
Source documents