evidence table

Calcium Vitamin D Fracture Randomized Trial Evidence Table

Structured evidence table for Calcium Vitamin D Fracture Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Calcium Vitamin D Fracture Randomized TrialStatistical analysis was performed using appropriate parametric and non-parametric tests, with P Results Both supplementation regimens significantly improved serum Vitamin D levels; however, the weekly regimen achieved higher levels at 12 weeks (32.8 ± 7.4 ng/mL vs.2Selvaraj NV (2026)Effect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
Calcium Vitamin D Fracture Randomized TrialSerum calcium levels increased and PTH levels decreased significantly, with greater changes observed in the weekly supplementation group.2Selvaraj NV (2026)Effect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
Calcium Vitamin D Fracture Randomized TrialConclusion Weekly high-dose Vitamin D supplementation resulted in superior biochemical correction and faster fracture healing compared to daily low-dose supplementation in Vitamin D-deficient patients with long-bone fractures.2Selvaraj NV (2026)Effect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
Calcium Vitamin D Fracture Randomized TrialIntroduction Vitamin D plays a critical role in bone metabolism and mineralization, and deficiency is highly prevalent among patients presenting with long-bone fractures.2Selvaraj NV (2026)Effect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
Calcium Vitamin D Fracture Randomized TrialMoreover, growing evidence suggesting an increased fall risk associated with high-dose bolus administration has necessitated a re-evaluation of safety assumptions.4Kong SH (2026)Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.
Calcium Vitamin D Fracture Randomized TrialUltimately, we advocate a shift away from a 'one-size-fits-all' paradigm toward targeted strategies that maximize efficacy while minimizing the risks associated with excess supplementation.4Kong SH (2026)Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.
Calcium Vitamin D Fracture Randomized TrialHowever, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations.4Kong SH (2026)Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.
topicCalcium Vitamin D Fracture Randomized Trial
claimStatistical analysis was performed using appropriate parametric and non-parametric tests, with P Results Both supplementation regimens significantly improved serum Vitamin D levels; however, the weekly regimen achieved higher levels at 12 weeks (32.8 ± 7.4 ng/mL vs.
evidence level2
citationSelvaraj NV (2026)
sourceEffect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
topicCalcium Vitamin D Fracture Randomized Trial
claimSerum calcium levels increased and PTH levels decreased significantly, with greater changes observed in the weekly supplementation group.
evidence level2
citationSelvaraj NV (2026)
sourceEffect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
topicCalcium Vitamin D Fracture Randomized Trial
claimConclusion Weekly high-dose Vitamin D supplementation resulted in superior biochemical correction and faster fracture healing compared to daily low-dose supplementation in Vitamin D-deficient patients with long-bone fractures.
evidence level2
citationSelvaraj NV (2026)
sourceEffect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
topicCalcium Vitamin D Fracture Randomized Trial
claimIntroduction Vitamin D plays a critical role in bone metabolism and mineralization, and deficiency is highly prevalent among patients presenting with long-bone fractures.
evidence level2
citationSelvaraj NV (2026)
sourceEffect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
topicCalcium Vitamin D Fracture Randomized Trial
claimMoreover, growing evidence suggesting an increased fall risk associated with high-dose bolus administration has necessitated a re-evaluation of safety assumptions.
evidence level4
citationKong SH (2026)
sourceRevisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.
topicCalcium Vitamin D Fracture Randomized Trial
claimUltimately, we advocate a shift away from a 'one-size-fits-all' paradigm toward targeted strategies that maximize efficacy while minimizing the risks associated with excess supplementation.
evidence level4
citationKong SH (2026)
sourceRevisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.
topicCalcium Vitamin D Fracture Randomized Trial
claimHowever, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations.
evidence level4
citationKong SH (2026)
sourceRevisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.

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Source documents

  1. Effect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.
  2. Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.