Vitamin D Depression Meta-analysis: What the Evidence Says

Quick Answer

Vitamin D Depression Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

Key Takeaways

• This page is generated only from sources stored in the Migaku evidence knowledge base.
• Current evidence mix: 2 systematic review.
• Claims should be interpreted with the source type, study design, population, and publication date in mind.
• This article is educational and does not replace care from a qualified clinician.

Evidence Map

What The Sources Report

• Additionally, the economic consequences are significant, resulting from decreased occupational productivity, increased absenteeism, and presenteeism. [Zainab Amani (2026); evidence level 1]
• Although the causes of PMS are not entirely clear, it is associated with an atypical sensitivity to regular cyclical hormonal shifts. [Zainab Amani (2026); evidence level 1]
• This review was conducted to (i) quantify the association between serum 25(OH)D deficiency and depression in a strictly longitudinal evidence base; (ii) examine effect modification by geographic region, deficiency threshold, and depression assessment approach; and (iii) assess methodological quality using design-appropriate tools applied in a mutually exclusive fashion. [Muacevic Alexander (2026); evidence level 1]
• Risk of Bias Assessment 10 11 Fourteen observational studies were assessed using the Newcastle-Ottawa Scale (NOS), which awards up to four stars for selection, two for comparability, and three for outcome assessment (maximum 9 stars). [Muacevic Alexander (2026); evidence level 1]

How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For vitamin D depression meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

References

• Zainab Amani (2026). Efficacy of Vitamin D Supplementation to Alleviate Premenstrual Syndrome Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. DOI: 10.3390/jcm15124828. PMCID: PMC13301900. PMID: 42355996. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13301900/
• Muacevic Alexander (2026). Association Between Low Vitamin D Levels and Depression: A Systematic Review and Meta-Analysis. DOI: 10.7759/cureus.109430. PMCID: PMC13286615. PMID: 42338858. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13286615/

Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.