Structured evidence table for Vitamin K2 Fracture Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Vitamin K2 Fracture Meta-Analysis | In the Global Burden of Disease 2019 analysis, low bone mineral density was associated with about 438,000 deaths and 166 million disability-adjusted life years, with large increases since 1990 (). | 1 | Zhang Zechen (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis |
| Vitamin K2 Fracture Meta-Analysis | In a cross-sectional study of 900 Chinese adults, higher ucOC was associated with lower BMD at the spine, femoral neck, and hip, and with higher P1NP and β-CTX, indicating increased turnover (). | 1 | Zhang Zechen (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis |
| Vitamin K2 Fracture Meta-Analysis | K2 deficiency has been linked to the “calcium paradox,” with insufficient skeletal deposition and increased vascular calcification (). | 1 | Zhang Zechen (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis |
| Vitamin K2 Fracture Meta-Analysis | It is characterized by low bone mass and deterioration of bone microarchitecture. | 1 | Zhang Zechen (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis |
| Vitamin K2 Fracture Meta-Analysis | Calcium and vitamin D are well-established for maintaining bone mass and reducing fracture risk, particularly in deficient or high-risk populations, whereas evidence supporting the roles of vitamin K, magnesium, and phosphorus is more limited and population specific. | 3 | da Silva Tiago Donizeti Bertolacini (2025) | Supplements for bone health |
| Vitamin K2 Fracture Meta-Analysis | 1 2 3 This review has three primary objectives: () to delineate the physiological functions of calcium, vitamin D, vitamin K, magnesium, and phosphorus in bone metabolism; () to summarize current dietary intake recommendations and evaluate the Brazilian context; () to synthesize evidence from meta-analyses and systematic reviews regarding their impact on bone health. | 3 | da Silva Tiago Donizeti Bertolacini (2025) | Supplements for bone health |
| Vitamin K2 Fracture Meta-Analysis | Conversely, elevated serum calcium levels suppress PTH secretion through negative feedback, leading to decreased bone resorption and reduced calcium reabsorption in the kidneys (,). | 3 | da Silva Tiago Donizeti Bertolacini (2025) | Supplements for bone health |
| Vitamin K2 Fracture Meta-Analysis | Bone health is determined by a complex interplay of genetic, hormonal, and environmental factors, with nutrient intake representing an important contributor to skeletal integrity. | 3 | da Silva Tiago Donizeti Bertolacini (2025) | Supplements for bone health |
Source documents