Structured evidence table for Vitamin K2 Bone Density Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Vitamin K2 Bone Density Meta-Analysis | Background Osteoporosis is a metabolic bone disease characterized by decreased bone mass and increased fracture risk. | 1 | Zhang Z (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis. |
| Vitamin K2 Bone Density Meta-Analysis | Vitamin K2 (VK2) increased osteocalcin (OC; MD 1.86, 95% CI 1.17-2.56) and bone-specific alkaline phosphatase (BAP; MD 1.49, 95% CI 0.98-2.00). | 1 | Zhang Z (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis. |
| Vitamin K2 Bone Density Meta-Analysis | It reduced undercarboxylated OC (ucOC; WMD -1.54, 95% CI -2.44 to -0.64) and tartrate-resistant acid phosphatase (TRAP; MD -0.83, 95% CI -1.21 to -0.46). | 1 | Zhang Z (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis. |
| Vitamin K2 Bone Density Meta-Analysis | Bone turnover markers, such as osteocalcin (OC), undercarboxylated osteocalcin (ucOC), and other biochemical indicators, are important for assessing bone metabolism. | 1 | Zhang Z (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis. |
| Vitamin K2 Bone Density Meta-Analysis | Evidence arises simultaneously from metabolic research, neuroendocrinology, hepatology, reproductive biology, and matrix biochemistry, yet these fields differ substantially in experimental models, assay methodologies, isoform definitions, and clinical endpoints. | 3 | Derwich Wiktor (2026) | Osteocalcin Beyond Bone: Molecular Mechanisms, Endocrine Networks, and Translational Perspectives Across Metabolism, Neurobiology, and Chronic Disease |
| Vitamin K2 Bone Density Meta-Analysis | This narrative review aims to unify these perspectives by: (a) summarizing structural determinants and carboxylation-dependent isoform biology; (b) outlining receptor-level mechanisms across target organs; (c) consolidating human evidence, including clamp-validated metabolic data; and (d) clarifying methodological and analytical limitations that critically shape the interpretation of OCN physiology. | 3 | Derwich Wiktor (2026) | Osteocalcin Beyond Bone: Molecular Mechanisms, Endocrine Networks, and Translational Perspectives Across Metabolism, Neurobiology, and Chronic Disease |
| Vitamin K2 Bone Density Meta-Analysis | As this is a narrative review, no formal eligibility criteria, protocol registration, or risk-of-bias tools were applied; studies were selected based on relevance, biological coherence, and their conceptual contribution to OCN physiology. | 3 | Derwich Wiktor (2026) | Osteocalcin Beyond Bone: Molecular Mechanisms, Endocrine Networks, and Translational Perspectives Across Metabolism, Neurobiology, and Chronic Disease |
| Vitamin K2 Bone Density Meta-Analysis | Bone is increasingly recognized as an endocrine organ, and osteocalcin (OCN) exemplifies this paradigm shift. | 3 | Derwich Wiktor (2026) | Osteocalcin Beyond Bone: Molecular Mechanisms, Endocrine Networks, and Translational Perspectives Across Metabolism, Neurobiology, and Chronic Disease |
Source documents