topicVitamin K2 Blood Pressure Meta-Analysis
claimVitamin D deficiency has been consistently associated with adverse outcomes, including increased susceptibility to cancers, diabetes, hypertension, and cardiovascular disease [,].
evidence level3
citationD’Elia Saverio (2025)
sourceModulation of Cardiometabolic Risk by Vitamin D and K2: Simple Supplementation or Real Drug? Uncovering the Pharmacological Properties
topicVitamin K2 Blood Pressure Meta-Analysis
claimEpidemiological studies further indicate that populations in regions with higher sun exposure exhibit lower prevalence of deficiency and reduced mortality from chronic disease [,].
evidence level3
citationD’Elia Saverio (2025)
sourceModulation of Cardiometabolic Risk by Vitamin D and K2: Simple Supplementation or Real Drug? Uncovering the Pharmacological Properties
topicVitamin K2 Blood Pressure Meta-Analysis
claimThese findings are reinforced by recent large-scale analyses: for example, a 2023 study in Clinical Nutrition involving nearly 410,000 UK Biobank participants reported that individuals with severe deficiency (<30 nmol/L) had a 10% increased risk of atherosclerotic cardiovascular disease and up to 35% higher risk of cardiovascular mortality [].
evidence level3
citationD’Elia Saverio (2025)
sourceModulation of Cardiometabolic Risk by Vitamin D and K2: Simple Supplementation or Real Drug? Uncovering the Pharmacological Properties
topicVitamin K2 Blood Pressure Meta-Analysis
claim1 2 3 4 5 6 7 6 Vitamin D, a pleiotropic secosteroid, exerts physiological effects far beyond its classical roles in calcium homeostasis and skeletal health [].
evidence level3
citationD’Elia Saverio (2025)
sourceModulation of Cardiometabolic Risk by Vitamin D and K2: Simple Supplementation or Real Drug? Uncovering the Pharmacological Properties
topicVitamin K2 Blood Pressure Meta-Analysis
claim1 2 3 5 6 7 8 9 More than two billion people are at risk of micronutrient deficiencies, which often involve multiple, rather than single, nutrients [,].
evidence level4
citationMuacevic Alexander (2026)
sourceA to Z of Health: An Evidence-Based Narrative Review of Multivitamin-Multimineral and Nutraceutical Supplementation
topicVitamin K2 Blood Pressure Meta-Analysis
claimThey are widely used to help individuals meet their daily nutrient requirements, support overall health, and address increased nutritional needs associated with pregnancy, aging, and illness.
evidence level4
citationMuacevic Alexander (2026)
sourceA to Z of Health: An Evidence-Based Narrative Review of Multivitamin-Multimineral and Nutraceutical Supplementation
topicVitamin K2 Blood Pressure Meta-Analysis
claimAccording to the National Health and Nutrition Examination Survey, MVM use in the USA increased from 35% in 1999-2000 [] to 49-52% between 2011 and 2014, with higher usage among women than men [-].
evidence level4
citationMuacevic Alexander (2026)
sourceA to Z of Health: An Evidence-Based Narrative Review of Multivitamin-Multimineral and Nutraceutical Supplementation
topicVitamin K2 Blood Pressure Meta-Analysis
claimThe most common deficiencies include vitamin A, folic acid, vitamin D, iron, iodine, and zinc, especially among children and women in low- and middle-income countries [-].
evidence level4
citationMuacevic Alexander (2026)
sourceA to Z of Health: An Evidence-Based Narrative Review of Multivitamin-Multimineral and Nutraceutical Supplementation