evidence table

Vitamin K Bone Density Meta-Analysis Evidence Table

Structured evidence table for Vitamin K Bone Density Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Vitamin K Bone Density Meta-Analysis4 4 5 FHA is a state of estrogen deficiency leading to detrimental skeletal effects, including insufficient peak bone mass accrual if onset is in adolescent/early adult life, low BMD, impaired bone microarchitecture, and resultant increased fracture risk ().1Efthymiadis Agathoklis (2026)Pharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
Vitamin K Bone Density Meta-AnalysisIndeed, fracture risk is 2-7 times higher than in age and sex-matched healthy women (,).1Efthymiadis Agathoklis (2026)Pharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
Vitamin K Bone Density Meta-Analysistransdermal 1 18 19 1 20 1 1 21 22 7 Selection of bone-directed therapy in FHA is typically guided by the outcome of non-pharmacological interventions and fracture risk.1Efthymiadis Agathoklis (2026)Pharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
Vitamin K Bone Density Meta-Analysis1 2 3 1 Functional hypothalamic amenorrhea (FHA) is a common reproductive disorder characterized by chronic anovulation due to stress, weight loss, excessive exercise, alone or in combination ().1Efthymiadis Agathoklis (2026)Pharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
Vitamin K Bone Density Meta-AnalysisIt is characterized by low bone mass and microarchitectural deterioration of bone matrix, resulting in increased bone fragility and fracture risk [,], impacting more frequently postmenopausal women and the elderly population.1Vesa Ştefan Cristian (2026)Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis
Vitamin K Bone Density Meta-AnalysisCarboxylated OC binds hydroxyapatite crystals and contributes to bone strength and mineralization, while undercarboxylated OC, associated with vitamin K deficiency or impaired recycling, is linked to reduced BMD and increased fracture risk [,].1Vesa Ştefan Cristian (2026)Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis
Vitamin K Bone Density Meta-AnalysisIn fact, this effect is clinically relevant enough to have been included in guidelines such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing [] and the Dutch Pharmacogenetics Working Group (DPWG) [].1Vesa Ştefan Cristian (2026)Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis
Vitamin K Bone Density Meta-Analysis1 2 1 2 2 1 2 3 Osteoporosis is a highly prevalent disease representing a major global health problem [,].1Vesa Ştefan Cristian (2026)Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis
topicVitamin K Bone Density Meta-Analysis
claim4 4 5 FHA is a state of estrogen deficiency leading to detrimental skeletal effects, including insufficient peak bone mass accrual if onset is in adolescent/early adult life, low BMD, impaired bone microarchitecture, and resultant increased fracture risk ().
evidence level1
citationEfthymiadis Agathoklis (2026)
sourcePharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
topicVitamin K Bone Density Meta-Analysis
claimIndeed, fracture risk is 2-7 times higher than in age and sex-matched healthy women (,).
evidence level1
citationEfthymiadis Agathoklis (2026)
sourcePharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
topicVitamin K Bone Density Meta-Analysis
claimtransdermal 1 18 19 1 20 1 1 21 22 7 Selection of bone-directed therapy in FHA is typically guided by the outcome of non-pharmacological interventions and fracture risk.
evidence level1
citationEfthymiadis Agathoklis (2026)
sourcePharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
topicVitamin K Bone Density Meta-Analysis
claim1 2 3 1 Functional hypothalamic amenorrhea (FHA) is a common reproductive disorder characterized by chronic anovulation due to stress, weight loss, excessive exercise, alone or in combination ().
evidence level1
citationEfthymiadis Agathoklis (2026)
sourcePharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
topicVitamin K Bone Density Meta-Analysis
claimIt is characterized by low bone mass and microarchitectural deterioration of bone matrix, resulting in increased bone fragility and fracture risk [,], impacting more frequently postmenopausal women and the elderly population.
evidence level1
citationVesa Ştefan Cristian (2026)
sourceAssociation Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis
topicVitamin K Bone Density Meta-Analysis
claimCarboxylated OC binds hydroxyapatite crystals and contributes to bone strength and mineralization, while undercarboxylated OC, associated with vitamin K deficiency or impaired recycling, is linked to reduced BMD and increased fracture risk [,].
evidence level1
citationVesa Ştefan Cristian (2026)
sourceAssociation Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis
topicVitamin K Bone Density Meta-Analysis
claimIn fact, this effect is clinically relevant enough to have been included in guidelines such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing [] and the Dutch Pharmacogenetics Working Group (DPWG) [].
evidence level1
citationVesa Ştefan Cristian (2026)
sourceAssociation Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis
topicVitamin K Bone Density Meta-Analysis
claim1 2 1 2 2 1 2 3 Osteoporosis is a highly prevalent disease representing a major global health problem [,].
evidence level1
citationVesa Ştefan Cristian (2026)
sourceAssociation Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis

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Source documents

  1. Pharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials
  2. Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis