topicVitamin E Visual Performance Randomized Trial
claimWhilst intraocular pressure (IOP) reduction remains the only evidence-based treatment strategy, disease progression commonly occurs despite adequate IOP control, indicating that IOP-independent mechanisms play critical roles in RGC degeneration.
evidence level4
citationRho Seungsoo (2026)
sourceProspects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies
topicVitamin E Visual Performance Randomized Trial
claimThis review synthesizes the current landscape of drug-based neuroprotective strategies, delineates preclinical from clinical evidence, and highlights emerging therapeutic targets.
evidence level4
citationRho Seungsoo (2026)
sourceProspects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies
topicVitamin E Visual Performance Randomized Trial
claimClinical evidence is detailed inand a summary including preclinical and clinical evidence is shown in.
evidence level4
citationRho Seungsoo (2026)
sourceProspects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies
topicVitamin E Visual Performance Randomized Trial
claimThese include excitotoxicity, mitochondrial dysfunction, oxidative stress, neuroinflammation, neurotrophic factor deprivation, and apoptosis (independently or in concert).
evidence level4
citationRho Seungsoo (2026)
sourceProspects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies
topicVitamin E Visual Performance Randomized Trial
claimIn MS patients, higher vitamin E levels were associated with better cognitive performance and lower disability.
evidence level4
citationBruno F (2026)
sourceSerum Vitamin E Levels in Multiple Sclerosis: Association with Diagnosis, Cognitive Function, Disability, and Depressive Symptoms.
topicVitamin E Visual Performance Randomized Trial
claimNo significant relationship was found between vitamin E levels and depressive symptoms.
evidence level4
citationBruno F (2026)
sourceSerum Vitamin E Levels in Multiple Sclerosis: Association with Diagnosis, Cognitive Function, Disability, and Depressive Symptoms.
topicVitamin E Visual Performance Randomized Trial
claimLongitudinal studies are needed to clarify whether low vitamin E levels influence the risk of developing MS, while randomized controlled trials are warranted to determine whether vitamin E supplementation may provide clinical benefits.
evidence level4
citationBruno F (2026)
sourceSerum Vitamin E Levels in Multiple Sclerosis: Association with Diagnosis, Cognitive Function, Disability, and Depressive Symptoms.
topicVitamin E Visual Performance Randomized Trial
claimMultiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system and the most common neurodegenerative disease in young adults, characterized by motor, sensory, visual, and cognitive impairments.
evidence level4
citationBruno F (2026)
sourceSerum Vitamin E Levels in Multiple Sclerosis: Association with Diagnosis, Cognitive Function, Disability, and Depressive Symptoms.