topicVitamin D Strength Meta-Analysis
claim1 2 3 4 Sarcopenia is a condition characterized by the progressive and generalized loss of muscle mass and function that primarily affects the older adult population, compromising their autonomy and quality of life, as it associated with a significantly increased risk of falls, hospitalizations, and mortality ().
evidence level3
citationCalderón Paula (2026)
sourceThe role of protein quality and amino acid composition in preventing sarcopenia and functional decline in older adults
topicVitamin D Strength Meta-Analysis
claimOne of the cornerstones of the prevention and treatment of sarcopenia is a protein-rich diet; however, current evidence suggests that standard protein intake recommendations may be insufficient to overcome the “anabolic resistance” characteristic of advanced age (,).
evidence level3
citationCalderón Paula (2026)
sourceThe role of protein quality and amino acid composition in preventing sarcopenia and functional decline in older adults
topicVitamin D Strength Meta-Analysis
claimThe main molecular mechanisms, mediated by NF- κB, mTOR, and TGF- β, involved in cellular senescence are associated with the activation of transcriptional programs that regulate gene expression, signaling pathways, and metabolism regulators, developing a senescence-associated secretory phenotype (SASP) (,).
evidence level3
citationCalderón Paula (2026)
sourceThe role of protein quality and amino acid composition in preventing sarcopenia and functional decline in older adults
topicVitamin D Strength Meta-Analysis
claimThis is due to age-related mechanisms of cellular senescence, oxidative stress, and low-grade chronic inflammation, all factors that exacerbate muscle catabolism and limit the regenerative capacity of the muscle tissue during aging ().
evidence level3
citationCalderón Paula (2026)
sourceThe role of protein quality and amino acid composition in preventing sarcopenia and functional decline in older adults
topicVitamin D Strength Meta-Analysis
claimThis emerging area highlights how genetic differences shape vitamin D absorption, metabolism, transport, and cellular action, ultimately influencing disease risk and health outcomes.
evidence level3
citationQahtan Fatima (2026)
sourceGenetic and epigenetic determinants of vitamin D metabolism: nutrigenomic insights for precision nutrition
topicVitamin D Strength Meta-Analysis
claimIn this context, this review synthesizes selected evidence on the genetic, epigenetic, and molecular determinants of vitamin D metabolism, with the aim of critically evaluating the strength, consistency, and limitations of current nutrigenomic findings and clarifying their implications and constraints for personalized nutrition and disease prevention.
evidence level3
citationQahtan Fatima (2026)
sourceGenetic and epigenetic determinants of vitamin D metabolism: nutrigenomic insights for precision nutrition
topicVitamin D Strength Meta-Analysis
claimThis limit understanding of how multiple genetic, epigenetic, and nutrigenomic factors work together to influence vitamin D status and disease risk.
evidence level3
citationQahtan Fatima (2026)
sourceGenetic and epigenetic determinants of vitamin D metabolism: nutrigenomic insights for precision nutrition
topicVitamin D Strength Meta-Analysis
claim1 Vitamin D is one of the most extensively studied micronutrients in modern nutritional science, particularly because of its wide-ranging effects on immune regulation, metabolic function, bone health, and gene expression.
evidence level3
citationQahtan Fatima (2026)
sourceGenetic and epigenetic determinants of vitamin D metabolism: nutrigenomic insights for precision nutrition