evidence table
Vitamin D Muscle Strength Meta-Analysis Evidence Table
Structured evidence table for Vitamin D Muscle Strength Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Vitamin D Muscle Strength Meta-Analysis | Supported by this biological plausibility and by observational studies demonstrating a robust inverse association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of fractures and falls, the medical community has witnessed a global surge in vitamin D screening and empiric supplementation over the past two decades []. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Vitamin D Muscle Strength Meta-Analysis | Furthermore, updated systematic reviews and meta-analyses published in 2025 have reinforced the conclusion that vitamin D supplementation does not reduce fall risk among community-dwelling older adults, with some analyses even suggesting potential harm at higher doses [-]. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Vitamin D Muscle Strength Meta-Analysis | Most notably, the 2024 Endocrine Society Clinical Practice Guideline now recommends against empiric vitamin D supplementation in healthy adults younger than 75 years, signaling a decisive transition from universal screening toward a more targeted, risk-based approach []. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Vitamin D Muscle Strength Meta-Analysis | 1 2 3 Vitamin D, often termed the ‘sunshine hormone,’ has been a cornerstone of musculoskeletal preventive medicine for decades. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Vitamin D Muscle Strength Meta-Analysis | In contrast, rapid nongenomic signaling is mediated by membrane-associated VDR or by protein disulfide isomerases A3 (PDIA3), also known as membrane-associated, rapid response steroid-binding (MARRS). | 4 | Lee Ga Young (2026) | Vitamin D-Mediated Immunoregulation in Degenerative Diseases: Insights into Cardiovascular, Neurodegenerative and Musculoskeletal Disorders |
| Vitamin D Muscle Strength Meta-Analysis | These pathways are closely associated with cellular metabolism, inflammatory regulation, and aging-related cellular dysfunction [,,]. | 4 | Lee Ga Young (2026) | Vitamin D-Mediated Immunoregulation in Degenerative Diseases: Insights into Cardiovascular, Neurodegenerative and Musculoskeletal Disorders |
| Vitamin D Muscle Strength Meta-Analysis | 12 13 14 15 Vitamin D insufficiency and deficiency are highly prevalent in ageing populations due to reduced cutaneous synthesis, inadequate dietary intake, and age-related changes in vitamin D metabolism []. | 4 | Lee Ga Young (2026) | Vitamin D-Mediated Immunoregulation in Degenerative Diseases: Insights into Cardiovascular, Neurodegenerative and Musculoskeletal Disorders |
| Vitamin D Muscle Strength Meta-Analysis | Degenerative diseases comprise a broad group of chronic, progressive disorders characterized by the gradual loss of cellular integrity, tissue function, and regenerative capacity. | 4 | Lee Ga Young (2026) | Vitamin D-Mediated Immunoregulation in Degenerative Diseases: Insights into Cardiovascular, Neurodegenerative and Musculoskeletal Disorders |
Source documents