topicVitamin D Immune Meta-Analysis
claimIn addition, vitamin D has been linked to reduced susceptibility to respiratory infections, attenuation of airway inflammation, and potential modulation of airway remodeling, all of which are relevant to asthma exacerbation and long-term disease control (,,,).
evidence level1
citationLiu Yongxiu (2026)
sourceEfficacy and safety of vitamin D in the treatment of asthma: an overview of systematic reviews and meta-analyses
topicVitamin D Immune Meta-Analysis
claimTherefore, a higher-level synthesis of the existing evidence is needed to critically examine its reliability, consistency, and certainty.
evidence level1
citationLiu Yongxiu (2026)
sourceEfficacy and safety of vitamin D in the treatment of asthma: an overview of systematic reviews and meta-analyses
topicVitamin D Immune Meta-Analysis
claimIn addition, the optimal supplementation dose, whether the benefits are mainly restricted to individuals with baseline vitamin D deficiency, and the long-term efficacy and safety of vitamin D supplementation remain uncertain and require further validation in high-quality evidence-based studies (,).
evidence level1
citationLiu Yongxiu (2026)
sourceEfficacy and safety of vitamin D in the treatment of asthma: an overview of systematic reviews and meta-analyses
topicVitamin D Immune Meta-Analysis
claim1 2 3 4 2 5 Asthma, a chronic inflammatory airway disorder, affects an estimated 260 million people globally, with its prevalence increasing annually.
evidence level1
citationLiu Yongxiu (2026)
sourceEfficacy and safety of vitamin D in the treatment of asthma: an overview of systematic reviews and meta-analyses
topicVitamin D Immune Meta-Analysis
claimThese immunological changes significantly contribute to increased morbidity, mortality, and healthcare costs among older adults ().
evidence level1
citationLi Die (2026)
sourceEffects of micronutrient supplementation on immune function in older adults: a meta-analysis
topicVitamin D Immune Meta-Analysis
claimFurthermore, immunosenescence is exacerbated by poor nutrition, particularly micronutrient deficiencies, which are common in the elderly due to reduced food intake, metabolic changes, and disease ().
evidence level1
citationLi Die (2026)
sourceEffects of micronutrient supplementation on immune function in older adults: a meta-analysis
topicVitamin D Immune Meta-Analysis
claimDeficiencies in these nutrients have been linked to weakened immune function, elevated inflammation, and increased susceptibility to diseases (–).
evidence level1
citationLi Die (2026)
sourceEffects of micronutrient supplementation on immune function in older adults: a meta-analysis
topicVitamin D Immune Meta-Analysis
claim1 2 3 4 5 Immunosenescence is the gradual deterioration of the immune system that occurs with biological aging ().
evidence level1
citationLi Die (2026)
sourceEffects of micronutrient supplementation on immune function in older adults: a meta-analysis