topicVitamin D Immune Function Randomized Trial
claimResults We found no significant difference in GVHD occurrence and levels of retinoids between the intervention and control groups at either of the two time points.
evidence level2
citationIversen PO (2026)
sourcePlasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
topicVitamin D Immune Function Randomized Trial
claimConclusion Whether routine vitamin A supplementation is warranted for GVHD prevention, needs further study.
evidence level2
citationIversen PO (2026)
sourcePlasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
topicVitamin D Immune Function Randomized Trial
claimIntroduction Whether retinoids and carotenoids impact on graft-versus-host disease (GVHD) following allogeneic stem cell transplantation (ASCT) is unknown.
evidence level2
citationIversen PO (2026)
sourcePlasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
topicVitamin D Immune Function Randomized Trial
claimMethods We conducted a 1:1 randomized controlled trial with extracorporeal photopheresis for GVHD-prophylaxis as the intervention.
evidence level2
citationIversen PO (2026)
sourcePlasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
topicVitamin D Immune Function Randomized Trial
claimStudies on vitamin D have increased tremendously since the vitamin D receptor VDR has been identified in the whole immune cell population, including macrophages, dendritic cells (DCs), T cells, and B cells [].
evidence level3
citationShende Sandesh (2026)
sourceVitamin D as an Immuno-Endocrine Modulator: Discovering Its Role in Autoimmune Disorders and Host Defense Mechanisms
topicVitamin D Immune Function Randomized Trial
claim11 2 12 13 14 Vitamin D was historically confined to skeletal biology, primarily associated with calcium–phosphate homeostasis and the prevention of rickets, osteomalacia, and osteoporosis [].
evidence level3
citationShende Sandesh (2026)
sourceVitamin D as an Immuno-Endocrine Modulator: Discovering Its Role in Autoimmune Disorders and Host Defense Mechanisms
topicVitamin D Immune Function Randomized Trial
claimAccumulating evidence indicates that hypovitaminosis D is common in autoimmune disorders such as multiple sclerosis (MS), type 1 diabetes mellitus (T1DM), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE), as well as in infectious diseases, including tuberculosis and acute respiratory tract infections [].
evidence level3
citationShende Sandesh (2026)
sourceVitamin D as an Immuno-Endocrine Modulator: Discovering Its Role in Autoimmune Disorders and Host Defense Mechanisms
topicVitamin D Immune Function Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 2 3 Vitamin D was historically confined to skeletal biology.
evidence level3
citationShende Sandesh (2026)
sourceVitamin D as an Immuno-Endocrine Modulator: Discovering Its Role in Autoimmune Disorders and Host Defense Mechanisms