evidence table
Vitamin D Depression Randomized Trial Evidence Table
Structured evidence table for Vitamin D Depression Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Vitamin D Depression Randomized Trial | Introduction Emerging real-world evidence suggests that folate supplementation may reduce suicidal ideation and behavior. | 3 | Noel C (2026) | The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review. |
| Vitamin D Depression Randomized Trial | One within-person cohort study found a 44% lower hazard of suicide-related emergency or hospital visits after treatment with folic acid (hazard ratio = 0.56) (and none in a parallel analysis of vitamin B12). | 3 | Noel C (2026) | The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review. |
| Vitamin D Depression Randomized Trial | One case-control study of patients with a history of suicidal behavior and ideation found lower suicidal ideation questionnaire scores with folinic acid ( P Discussion Evidence linking folate supplementation to reduced suicidal behavior is promising but limited by heterogeneity in design, sample size, folate formulation, and outcome measurement. | 3 | Noel C (2026) | The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review. |
| Vitamin D Depression Randomized Trial | We conducted a scoping review to evaluate current hypothesis-testing literature on folate supplementation and outcomes related to suicide. | 3 | Noel C (2026) | The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review. |
| Vitamin D Depression Randomized Trial | Background and purpose Evidence regarding the association between vitamin E and depression is inconsistent. | 4 | Zhao D (2026) | Genetic Causal Association Between Vitamin E and Depression: A Two-Sample Mendelian Randomization Study. |
| Vitamin D Depression Randomized Trial | To address this uncertainty, we employed a two-sample Mendelian randomization (MR) approach to evaluate the potential causal effect of vitamin E on depression risk. | 4 | Zhao D (2026) | Genetic Causal Association Between Vitamin E and Depression: A Two-Sample Mendelian Randomization Study. |
| Vitamin D Depression Randomized Trial | Conclusions The present MR analysis indicated that genetically predicted vitamin E was not causally associated with the risk of depression. | 4 | Zhao D (2026) | Genetic Causal Association Between Vitamin E and Depression: A Two-Sample Mendelian Randomization Study. |
Source documents