topicVitamin D Bone Strength Randomized Trial
claimThe first group includes supplements supported by a robust theoretical foundation and extensive empirical evidence confirming their efficacy and safety.
evidence level1
citationSoltani Mohammad (2026)
sourceVitamin D Status and Supplementation and the Functional Outcomes of Human Musculoskeletal Tissues: A Stratified Systematic Review
topicVitamin D Bone Strength Randomized Trial
claimThe second group comprises supplements with a plausible scientific rationale but inconsistent evidence regarding their effectiveness, necessitating further research.
evidence level1
citationSoltani Mohammad (2026)
sourceVitamin D Status and Supplementation and the Functional Outcomes of Human Musculoskeletal Tissues: A Stratified Systematic Review
topicVitamin D Bone Strength Randomized Trial
claimIts anti‐inflammatory properties and role in reducing fracture risk, muscle weakness, and tendinopathy are well‐documented [,].
evidence level1
citationSoltani Mohammad (2026)
sourceVitamin D Status and Supplementation and the Functional Outcomes of Human Musculoskeletal Tissues: A Stratified Systematic Review
topicVitamin D Bone Strength Randomized Trial
claim1 2 3 1 4 5 6 7 8 9 10 11 Dietary supplements, defined as nutrients or compounds ingested to enhance health or performance beyond habitual diets [], are widely used by athletes and the general population [,].
evidence level1
citationSoltani Mohammad (2026)
sourceVitamin D Status and Supplementation and the Functional Outcomes of Human Musculoskeletal Tissues: A Stratified Systematic Review
topicVitamin D Bone Strength Randomized Trial
claimSpecifically, 48.0% (12/25) of participants in the alfacalcidol group and 12.0% (3/25) in the control group achieved improvement in muscle mass or function, yielding an absolute difference of 36.0% (95% CI 12.6% – 59.4%; P = 0.005), with a relative risk (RR) of 1.69 (95% CI 1.13–2.53).
evidence level2
citationWang L (2026)
sourceEffect of active vitamin D supplementation on muscle mass and function in peritoneal dialysis patients with sarcopenia: a randomized controlled trial.
topicVitamin D Bone Strength Randomized Trial
claimThe data regarding the influence of active vitamin D supplementation on muscle mass and function in end-stage renal disease (ESRD) patients have been inconclusive.
evidence level2
citationWang L (2026)
sourceEffect of active vitamin D supplementation on muscle mass and function in peritoneal dialysis patients with sarcopenia: a randomized controlled trial.
topicVitamin D Bone Strength Randomized Trial
claimOur study aimed to determine the effectiveness of vitamin D supplementation on the alterations in muscle mass and function in peritoneal dialysis (PD) patients with sarcopenia.
evidence level2
citationWang L (2026)
sourceEffect of active vitamin D supplementation on muscle mass and function in peritoneal dialysis patients with sarcopenia: a randomized controlled trial.