topicVitamin C Sleep Quality Meta-Analysis
claimInsomnia, daytime sleepiness, mood changes, decreased adherence to treatment and increased cardiovascular risk through increased sympathetic activity have been reported to be linked with RLS severe form ().
evidence level1
citationZhang Juntao (2026)
sourceEfficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
topicVitamin C Sleep Quality Meta-Analysis
claimNevertheless, there is a lack of consistent evidence and safety concerns that make them not popular first-line treatment options ().
evidence level1
citationZhang Juntao (2026)
sourceEfficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
topicVitamin C Sleep Quality Meta-Analysis
claimThe current reviews are either older or mostly narrative in nature without rigorous quantitative synthesis of the existing evidence (,).
evidence level1
citationZhang Juntao (2026)
sourceEfficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
topicVitamin C Sleep Quality Meta-Analysis
claim1 2 3 4 5 6 7 8 9 10 11 12 43 Restless Legs Syndrome (RLS), or Willis–Ekbom disease, is a chronic neurological condition marked by an uncomfortable urge to move the legs.
evidence level1
citationZhang Juntao (2026)
sourceEfficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis
topicVitamin C Sleep Quality Meta-Analysis
claimAJ combined with manual acupuncture (MA) significantly reduced PSQI scores based on the results of the pairwise meta-analysis and was among the most effective interventions based on the results of the network meta-analysis.
evidence level1
citationZhao H (2026)
sourceClinical effectiveness and economic evaluation of acupoint injection for the treatment of primary insomnia: a systematic review and network meta-analysis.
topicVitamin C Sleep Quality Meta-Analysis
claimThe cost-effectiveness analysis revealed that AJ combined with MA was associated with better outcomes at modest additional costs, as indicated by the favorable incremental cost-effectiveness ratio (ICER) values for PSQI improvement and additional responders.
evidence level1
citationZhao H (2026)
sourceClinical effectiveness and economic evaluation of acupoint injection for the treatment of primary insomnia: a systematic review and network meta-analysis.
topicVitamin C Sleep Quality Meta-Analysis
claimConclusions This study is the first to comprehensively synthesize evidence on the clinical effectiveness and cost-effectiveness of acupoint injection for primary insomnia.
evidence level1
citationZhao H (2026)
sourceClinical effectiveness and economic evaluation of acupoint injection for the treatment of primary insomnia: a systematic review and network meta-analysis.
topicVitamin C Sleep Quality Meta-Analysis
claimBackground Primary insomnia is a highly prevalent sleep disorder that significantly affects quality of life.
evidence level1
citationZhao H (2026)
sourceClinical effectiveness and economic evaluation of acupoint injection for the treatment of primary insomnia: a systematic review and network meta-analysis.