Vitamin C Immune Support Randomized Trial Evidence Table

Structured evidence table for Vitamin C Immune Support Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Vitamin C Immune Support Randomized TrialResults We found no significant difference in GVHD occurrence and levels of retinoids between the intervention and control groups at either of the two time points.2Iversen PO (2026)Plasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
Vitamin C Immune Support Randomized TrialConclusion Whether routine vitamin A supplementation is warranted for GVHD prevention, needs further study.2Iversen PO (2026)Plasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
Vitamin C Immune Support Randomized TrialIntroduction Whether retinoids and carotenoids impact on graft-versus-host disease (GVHD) following allogeneic stem cell transplantation (ASCT) is unknown.2Iversen PO (2026)Plasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
Vitamin C Immune Support Randomized TrialMethods We conducted a 1:1 randomized controlled trial with extracorporeal photopheresis for GVHD-prophylaxis as the intervention.2Iversen PO (2026)Plasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
Vitamin C Immune Support Randomized TrialResistance often develops through genetic changes in fungi, such as mutations in drug targets or increased drug efflux.3Akimbekov Nuraly S. (2026)Vitamin D–AMP axis in host defense against fungal infections
Vitamin C Immune Support Randomized TrialThis growing problem poses a serious challenge to public health, limiting treatment options and increasing the risk of adverse outcomes for patients, particularly those with invasive candidiasis and mold disease ().3Akimbekov Nuraly S. (2026)Vitamin D–AMP axis in host defense against fungal infections
Vitamin C Immune Support Randomized TrialGrowing evidence suggests that vitamin D increases innate immunity by regulating the production of AMPs ().3Akimbekov Nuraly S. (2026)Vitamin D–AMP axis in host defense against fungal infections
Vitamin C Immune Support Randomized TrialThis trend is concerning, as it is coupled with the emergence of drug-resistant fungal strains and limited treatment options, leading to a substantial global health burden ().3Akimbekov Nuraly S. (2026)Vitamin D–AMP axis in host defense against fungal infections
topicVitamin C Immune Support Randomized Trial
claimResults We found no significant difference in GVHD occurrence and levels of retinoids between the intervention and control groups at either of the two time points.
evidence level2
citationIversen PO (2026)
sourcePlasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
topicVitamin C Immune Support Randomized Trial
claimConclusion Whether routine vitamin A supplementation is warranted for GVHD prevention, needs further study.
evidence level2
citationIversen PO (2026)
sourcePlasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
topicVitamin C Immune Support Randomized Trial
claimIntroduction Whether retinoids and carotenoids impact on graft-versus-host disease (GVHD) following allogeneic stem cell transplantation (ASCT) is unknown.
evidence level2
citationIversen PO (2026)
sourcePlasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
topicVitamin C Immune Support Randomized Trial
claimMethods We conducted a 1:1 randomized controlled trial with extracorporeal photopheresis for GVHD-prophylaxis as the intervention.
evidence level2
citationIversen PO (2026)
sourcePlasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
topicVitamin C Immune Support Randomized Trial
claimResistance often develops through genetic changes in fungi, such as mutations in drug targets or increased drug efflux.
evidence level3
citationAkimbekov Nuraly S. (2026)
sourceVitamin D–AMP axis in host defense against fungal infections
topicVitamin C Immune Support Randomized Trial
claimThis growing problem poses a serious challenge to public health, limiting treatment options and increasing the risk of adverse outcomes for patients, particularly those with invasive candidiasis and mold disease ().
evidence level3
citationAkimbekov Nuraly S. (2026)
sourceVitamin D–AMP axis in host defense against fungal infections
topicVitamin C Immune Support Randomized Trial
claimGrowing evidence suggests that vitamin D increases innate immunity by regulating the production of AMPs ().
evidence level3
citationAkimbekov Nuraly S. (2026)
sourceVitamin D–AMP axis in host defense against fungal infections
topicVitamin C Immune Support Randomized Trial
claimThis trend is concerning, as it is coupled with the emergence of drug-resistant fungal strains and limited treatment options, leading to a substantial global health burden ().
evidence level3
citationAkimbekov Nuraly S. (2026)
sourceVitamin D–AMP axis in host defense against fungal infections

Source documents

  1. Plasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.
  2. Vitamin D–AMP axis in host defense against fungal infections