topicVitamin C Cold Meta-Analysis
claimBundle care significantly reduced thirst intensity compared with usual care (SMD: -4.50, 95% CI: -6.12 to -2.88).
evidence level1
citationShen X (2026)
sourceEffects of Non-Pharmacological Interventions on Degree of Thirst and Oral Mucosal Moisture in Critically Ill Patients: A Systematic Review and Meta-Analysis.
topicVitamin C Cold Meta-Analysis
claimBackground Thirst is a common symptom among critically ill patients and may lead to a series of complications.
evidence level1
citationShen X (2026)
sourceEffects of Non-Pharmacological Interventions on Degree of Thirst and Oral Mucosal Moisture in Critically Ill Patients: A Systematic Review and Meta-Analysis.
topicVitamin C Cold Meta-Analysis
claimTherefore, effective non-pharmacological strategies to alleviate thirst and manage oral dryness are critical.
evidence level1
citationShen X (2026)
sourceEffects of Non-Pharmacological Interventions on Degree of Thirst and Oral Mucosal Moisture in Critically Ill Patients: A Systematic Review and Meta-Analysis.
topicVitamin C Cold Meta-Analysis
claimCurrent evidence suggests that CIVD is mediated by 1) impaired transfer of noradrenaline from sympathetic nerves to the smooth muscle of the arterio-venous anastomoses or 2) nitric oxide release from these nerves, however, further research is needed to confirm these mechanisms.
evidence level1
citationWeller RS (2026)
sourceCold-induced vasodilation: A meta-analysis.
topicVitamin C Cold Meta-Analysis
claimNearly a century ago, cold-induced vasodilation (CIVD) was first described as repeated episodes of warm blood flow to the fingers during cold-water immersion.
evidence level1
citationWeller RS (2026)
sourceCold-induced vasodilation: A meta-analysis.
topicVitamin C Cold Meta-Analysis
claimSince then, hundreds of studies have examined this phenomenon, yet no comprehensive synthesis exists.
evidence level1
citationWeller RS (2026)
sourceCold-induced vasodilation: A meta-analysis.