topicVitamin B6 Sleep Meta-Analysis
claimAdditionally, we performed a risk-of-bias analysis of the studies compatible with the RoB2 tool.
evidence level1
citationTortajada J (2026)
sourceClinical outcomes of mitochondrial-enhancing nutraceutical supplementation in psychiatric disorders: A systematic review.
topicVitamin B6 Sleep Meta-Analysis
claimOverall, the risk of bias was high, and the methodological quality was generally low.
evidence level1
citationTortajada J (2026)
sourceClinical outcomes of mitochondrial-enhancing nutraceutical supplementation in psychiatric disorders: A systematic review.
topicVitamin B6 Sleep Meta-Analysis
claimBackground Nutraceutical supplementation targeting mitochondrial function has been proposed as a beneficial therapeutic strategy to improve physical and mental health in psychiatric patients.
evidence level1
citationTortajada J (2026)
sourceClinical outcomes of mitochondrial-enhancing nutraceutical supplementation in psychiatric disorders: A systematic review.
topicVitamin B6 Sleep Meta-Analysis
claimAims To summarise the results of studies evaluating nutraceutical supplementation targeting mitochondrial function in patients with psychiatric disorders.
evidence level1
citationTortajada J (2026)
sourceClinical outcomes of mitochondrial-enhancing nutraceutical supplementation in psychiatric disorders: A systematic review.
topicVitamin B6 Sleep Meta-Analysis
claimConcurrently, the number of individuals affected by dementia is anticipated to nearly triple by 2050, with associated treatment costs projected to reach US$2.8 trillion by 2030 [].
evidence level1
citationLiu Xing (2026)
sourceNutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis
topicVitamin B6 Sleep Meta-Analysis
claimIn addition, omega-3 fatty acids support synaptic plasticity and exert anti-inflammatory effects; however, evidence is mixed, as randomized trials in healthy older adults show limited benefits [,], while several analyses report modest improvements in aged or MCI patients [,].
evidence level1
citationLiu Xing (2026)
sourceNutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis
topicVitamin B6 Sleep Meta-Analysis
claimObservational studies and recent trials involving antioxidant nutrients, such as pomegranate juice and resveratrol, alongside polyphenols, suggest potential protection for specific cognitive domains (e.g., memory) and reduced dementia risk, although effects are heterogeneous and causality remains unconfirmed [,].
evidence level1
citationLiu Xing (2026)
sourceNutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis
topicVitamin B6 Sleep Meta-Analysis
claim1 2 3 4 5 6 7 8 9 10 The World Health Organization (WHO) projects that by 2050, the global population aged 60 and above will reach 2.1 billion, highlighting the inevitability of global aging [].
evidence level1
citationLiu Xing (2026)
sourceNutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis