Vitamin B6 PMS Meta-Analysis Evidence Table

Structured evidence table for Vitamin B6 PMS Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Vitamin B6 PMS Meta-AnalysisThe quality of the selected articles was assessed utilizing the Cochrane Risk of Bias assessment checklist.1Sharifipour F (2025)The effectiveness of vitamin B6 in reducing mastalgia: a systematic review and meta-analysis.
Vitamin B6 PMS Meta-AnalysisThe combined analysis of these three studies indicated that there were no differences between the two groups of vitamins B6 and placebo in a reduction of pain intensity (SMD = -3.57, 95% CI: -9.15 to 2.01; very low certainty of evidence), with high heterogeneity among the studies (I² = 99.56%).1Sharifipour F (2025)The effectiveness of vitamin B6 in reducing mastalgia: a systematic review and meta-analysis.
Vitamin B6 PMS Meta-AnalysisConclusion This meta-analysis did not demonstrate a statistically significant effect of vitamin B6 on mastalgia severity.1Sharifipour F (2025)The effectiveness of vitamin B6 in reducing mastalgia: a systematic review and meta-analysis.
Vitamin B6 PMS Meta-AnalysisBackground Mastalgia represents the most frequent complaint among women at some point during their lives that can have a profound impact on both the physical and mental well-being of individuals affected by this condition.1Sharifipour F (2025)The effectiveness of vitamin B6 in reducing mastalgia: a systematic review and meta-analysis.
Vitamin B6 PMS Meta-AnalysisSome evidence suggests that women with Rh-negative blood type may have a higher likelihood of developing premenstrual symptoms, although mechanistic explanations remain speculative and findings are not yet consistent across studies.4Martire Francesco Giuseppe (2026)Premenstrual Syndrome and Nutritional Factors: A Narrative Review of Current Evidence and Clinical Implications
Vitamin B6 PMS Meta-AnalysisHigh caffeine intake has also been linked to increased PMS risk, possibly through its impact on sleep quality, anxiety, and neuroendocrine regulation.4Martire Francesco Giuseppe (2026)Premenstrual Syndrome and Nutritional Factors: A Narrative Review of Current Evidence and Clinical Implications
Vitamin B6 PMS Meta-Analysis13 3 14 15 16 17 18 19 20 13 21 22 23 13 13 3 22 The etiopathogenesis of PMS and PMDD is multifactorial and remains only partially understood, but current evidence indicates that symptoms arise from a complex interplay between normal ovarian steroid fluctuations and an underlying neurobiological vulnerability present only in susceptible individuals.4Martire Francesco Giuseppe (2026)Premenstrual Syndrome and Nutritional Factors: A Narrative Review of Current Evidence and Clinical Implications
Vitamin B6 PMS Meta-Analysis1 2 3 4 5 6 Premenstrual syndrome is a gynaecological and psychiatric disorder that reduces the quality of life of affected patients [].4Martire Francesco Giuseppe (2026)Premenstrual Syndrome and Nutritional Factors: A Narrative Review of Current Evidence and Clinical Implications

Source documents

  1. The effectiveness of vitamin B6 in reducing mastalgia: a systematic review and meta-analysis.
  2. Premenstrual Syndrome and Nutritional Factors: A Narrative Review of Current Evidence and Clinical Implications