evidence table

Vitamin B12 Mood Randomized Trial Evidence Table

Structured evidence table for Vitamin B12 Mood Randomized Trial, generated from 1 reusable source document in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Vitamin B12 Mood Randomized TrialWe present guidance from major health authorities, which advises against routine testing in asymptomatic individuals without risk factors.4Yepes-Calderón M (2026)Vitamin B<sub>12</sub> Supplementation: Is More Always Better?
Vitamin B12 Mood Randomized TrialObservational studies associate B 12 supplementation and higher circulating B 12 levels with increased risks of malignancy.4Yepes-Calderón M (2026)Vitamin B<sub>12</sub> Supplementation: Is More Always Better?
Vitamin B12 Mood Randomized TrialHowever, these findings are inconsistent, and current evidence is insufficient to establish causality, as potential reverse causation remains a major concern.4Yepes-Calderón M (2026)Vitamin B<sub>12</sub> Supplementation: Is More Always Better?
Vitamin B12 Mood Randomized TrialVitamin B 12 supplementation among people without proven deficiency has become popularized, driven by perceptions of (i) frequent underdiagnosis of deficiency, (ii) promotion as a natural enhancer of well-being, and (iii) a favourable safety profile.4Yepes-Calderón M (2026)Vitamin B<sub>12</sub> Supplementation: Is More Always Better?
topicVitamin B12 Mood Randomized Trial
claimWe present guidance from major health authorities, which advises against routine testing in asymptomatic individuals without risk factors.
evidence level4
citationYepes-Calderón M (2026)
sourceVitamin B<sub>12</sub> Supplementation: Is More Always Better?
topicVitamin B12 Mood Randomized Trial
claimObservational studies associate B 12 supplementation and higher circulating B 12 levels with increased risks of malignancy.
evidence level4
citationYepes-Calderón M (2026)
sourceVitamin B<sub>12</sub> Supplementation: Is More Always Better?
topicVitamin B12 Mood Randomized Trial
claimHowever, these findings are inconsistent, and current evidence is insufficient to establish causality, as potential reverse causation remains a major concern.
evidence level4
citationYepes-Calderón M (2026)
sourceVitamin B<sub>12</sub> Supplementation: Is More Always Better?
topicVitamin B12 Mood Randomized Trial
claimVitamin B 12 supplementation among people without proven deficiency has become popularized, driven by perceptions of (i) frequent underdiagnosis of deficiency, (ii) promotion as a natural enhancer of well-being, and (iii) a favourable safety profile.
evidence level4
citationYepes-Calderón M (2026)
sourceVitamin B<sub>12</sub> Supplementation: Is More Always Better?

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Source documents

  1. Vitamin B<sub>12</sub> Supplementation: Is More Always Better?