topicVitamin B12 Fatigue Meta-Analysis
claimThere is also the assumption that a water-soluble vitamin carries negligible risk [,].
evidence level3
citationYepes-Calderón Manuela (2026)
sourceVitamin B 12 Supplementation: Is More Always Better?
evidence table
Vitamin B12 Fatigue Meta-Analysis Evidence Table
Structured evidence table for Vitamin B12 Fatigue Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Vitamin B12 Fatigue Meta-Analysis | There is also the assumption that a water-soluble vitamin carries negligible risk [,]. | 3 | Yepes-Calderón Manuela (2026) | Vitamin B 12 Supplementation: Is More Always Better? |
| Vitamin B12 Fatigue Meta-Analysis | A critical appraisal is warranted to delineate evidence-based indications, clarify benefits and harms in replete populations, and guide prudent dosing and monitoring. | 3 | Yepes-Calderón Manuela (2026) | Vitamin B 12 Supplementation: Is More Always Better? |
| Vitamin B12 Fatigue Meta-Analysis | To investigate effects beyond deficiency correction, we examined evidence on vitamin Bpharmacokinetics and routes of administration, as well as studies assessing potential health benefits in non-deficient individuals. | 3 | Yepes-Calderón Manuela (2026) | Vitamin B 12 Supplementation: Is More Always Better? |
| Vitamin B12 Fatigue Meta-Analysis | 12 12 1 2 3 4 4 5 Vitamin Bsupplements are usually prescribed to cover deficiencies and, less frequently, as cofactor therapy for rare inborn errors of metabolism [,]. | 3 | Yepes-Calderón Manuela (2026) | Vitamin B 12 Supplementation: Is More Always Better? |
| Vitamin B12 Fatigue Meta-Analysis | Vitamin Bdeficiency is particularly common during pregnancy and has been associated with adverse pregnancy outcomes, including spontaneous abortion, low birthweight, intrauterine growth restriction, and neural tube defects [,,,]. | 3 | Sley Erin G (2026) | Vitamin B 12 supplementation for anaemia, vitamin B 12 status, and health outcomes in women of reproductive age |
| Vitamin B12 Fatigue Meta-Analysis | Women of reproductive age are at increased risk of anaemia and micronutrient deficiencies, including vitamin Bdeficiency [,,,]. | 3 | Sley Erin G (2026) | Vitamin B 12 supplementation for anaemia, vitamin B 12 status, and health outcomes in women of reproductive age |
| Vitamin B12 Fatigue Meta-Analysis | Emerging evidence from observational studies suggests a link between lower vitamin Bstatus and metabolic health problems (such as impaired glucose metabolism, reduced insulin sensitivity, diabetes [,,,,,,,]) and cardiovascular outcomes [,,]. | 3 | Sley Erin G (2026) | Vitamin B 12 supplementation for anaemia, vitamin B 12 status, and health outcomes in women of reproductive age |
| Vitamin B12 Fatigue Meta-Analysis | 1 2 3 2 Vitamin Bis a water‐soluble B‐vitamin required for DNA synthesis and methylation, red blood cell formation, and folate metabolism [,,]. | 3 | Sley Erin G (2026) | Vitamin B 12 supplementation for anaemia, vitamin B 12 status, and health outcomes in women of reproductive age |
topicVitamin B12 Fatigue Meta-Analysis
claimA critical appraisal is warranted to delineate evidence-based indications, clarify benefits and harms in replete populations, and guide prudent dosing and monitoring.
evidence level3
citationYepes-Calderón Manuela (2026)
sourceVitamin B 12 Supplementation: Is More Always Better?
topicVitamin B12 Fatigue Meta-Analysis
claimTo investigate effects beyond deficiency correction, we examined evidence on vitamin Bpharmacokinetics and routes of administration, as well as studies assessing potential health benefits in non-deficient individuals.
evidence level3
citationYepes-Calderón Manuela (2026)
sourceVitamin B 12 Supplementation: Is More Always Better?
topicVitamin B12 Fatigue Meta-Analysis
claim12 12 1 2 3 4 4 5 Vitamin Bsupplements are usually prescribed to cover deficiencies and, less frequently, as cofactor therapy for rare inborn errors of metabolism [,].
evidence level3
citationYepes-Calderón Manuela (2026)
sourceVitamin B 12 Supplementation: Is More Always Better?
topicVitamin B12 Fatigue Meta-Analysis
claimVitamin Bdeficiency is particularly common during pregnancy and has been associated with adverse pregnancy outcomes, including spontaneous abortion, low birthweight, intrauterine growth restriction, and neural tube defects [,,,].
evidence level3
citationSley Erin G (2026)
sourceVitamin B 12 supplementation for anaemia, vitamin B 12 status, and health outcomes in women of reproductive age
topicVitamin B12 Fatigue Meta-Analysis
claimWomen of reproductive age are at increased risk of anaemia and micronutrient deficiencies, including vitamin Bdeficiency [,,,].
evidence level3
citationSley Erin G (2026)
sourceVitamin B 12 supplementation for anaemia, vitamin B 12 status, and health outcomes in women of reproductive age
topicVitamin B12 Fatigue Meta-Analysis
claimEmerging evidence from observational studies suggests a link between lower vitamin Bstatus and metabolic health problems (such as impaired glucose metabolism, reduced insulin sensitivity, diabetes [,,,,,,,]) and cardiovascular outcomes [,,].
evidence level3
citationSley Erin G (2026)
sourceVitamin B 12 supplementation for anaemia, vitamin B 12 status, and health outcomes in women of reproductive age
topicVitamin B12 Fatigue Meta-Analysis
claim1 2 3 2 Vitamin Bis a water‐soluble B‐vitamin required for DNA synthesis and methylation, red blood cell formation, and folate metabolism [,,].
evidence level3
citationSley Erin G (2026)
sourceVitamin B 12 supplementation for anaemia, vitamin B 12 status, and health outcomes in women of reproductive age
Source documents