topicVitamin B12 Cognition Randomized Trial
claimBackground/objectives Evidence linking vitamins D and B 12 to psychiatric outcomes remains heterogeneous across designs, populations, phenotypes, exposures, and outcome formats.
evidence level1
citationMoroianu LA (2026)
sourceVitamin D and Vitamin B<sub>12</sub> in Psychiatric Disorders: An Exploratory Systematic Review and Meta-Analysis of Nutrient-Specific Status and Supplementation Evidence.
topicVitamin B12 Cognition Randomized Trial
claimMethods We conducted a PRISMA 2020 systematic review and exploratory meta-analysis of nutrient-specific status and supplementation evidence.
evidence level1
citationMoroianu LA (2026)
sourceVitamin D and Vitamin B<sub>12</sub> in Psychiatric Disorders: An Exploratory Systematic Review and Meta-Analysis of Nutrient-Specific Status and Supplementation Evidence.
topicVitamin B12 Cognition Randomized Trial
claimEffects were harmonized to odds ratios (ORs) for cross-family comparability and pooled using Hartung-Knapp random-effects models; supplementation evidence was additionally interpreted on the standardized mean difference (SMD) scale.
evidence level1
citationMoroianu LA (2026)
sourceVitamin D and Vitamin B<sub>12</sub> in Psychiatric Disorders: An Exploratory Systematic Review and Meta-Analysis of Nutrient-Specific Status and Supplementation Evidence.
topicVitamin B12 Cognition Randomized Trial
claimThere is also the assumption that a water-soluble vitamin carries negligible risk [,].
evidence level3
citationYepes-Calderón Manuela (2026)
sourceVitamin B 12 Supplementation: Is More Always Better?
topicVitamin B12 Cognition Randomized Trial
claimA critical appraisal is warranted to delineate evidence-based indications, clarify benefits and harms in replete populations, and guide prudent dosing and monitoring.
evidence level3
citationYepes-Calderón Manuela (2026)
sourceVitamin B 12 Supplementation: Is More Always Better?
topicVitamin B12 Cognition Randomized Trial
claimTo investigate effects beyond deficiency correction, we examined evidence on vitamin Bpharmacokinetics and routes of administration, as well as studies assessing potential health benefits in non-deficient individuals.
evidence level3
citationYepes-Calderón Manuela (2026)
sourceVitamin B 12 Supplementation: Is More Always Better?
topicVitamin B12 Cognition Randomized Trial
claim12 12 1 2 3 4 4 5 Vitamin Bsupplements are usually prescribed to cover deficiencies and, less frequently, as cofactor therapy for rare inborn errors of metabolism [,].
evidence level3
citationYepes-Calderón Manuela (2026)
sourceVitamin B 12 Supplementation: Is More Always Better?