topicVitamin B1 Cognition Randomized Trial
claimConcurrently, the number of individuals affected by dementia is anticipated to nearly triple by 2050, with associated treatment costs projected to reach US$2.8 trillion by 2030 [].
evidence level1
citationLiu Xing (2026)
sourceNutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis
topicVitamin B1 Cognition Randomized Trial
claimIn addition, omega-3 fatty acids support synaptic plasticity and exert anti-inflammatory effects; however, evidence is mixed, as randomized trials in healthy older adults show limited benefits [,], while several analyses report modest improvements in aged or MCI patients [,].
evidence level1
citationLiu Xing (2026)
sourceNutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis
topicVitamin B1 Cognition Randomized Trial
claimObservational studies and recent trials involving antioxidant nutrients, such as pomegranate juice and resveratrol, alongside polyphenols, suggest potential protection for specific cognitive domains (e.g., memory) and reduced dementia risk, although effects are heterogeneous and causality remains unconfirmed [,].
evidence level1
citationLiu Xing (2026)
sourceNutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis
topicVitamin B1 Cognition Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 The World Health Organization (WHO) projects that by 2050, the global population aged 60 and above will reach 2.1 billion, highlighting the inevitability of global aging [].
evidence level1
citationLiu Xing (2026)
sourceNutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis
topicVitamin B1 Cognition Randomized Trial
claimRecent evidence shows that trillions of microorganisms in the gastrointestinal tract (GI tract) act as active regulators of various metabolic functions, including but not limited to neurologic function, mood, sleep quality, cognitive performance, and pain perception [...].
evidence level4
citationMarkonda L (2026)
sourceDiet and Microbiota-Gut-Brain Axis: A Novel Nutritional Therapy.