topicHyaluronic Acid Joint Pain Meta-Analysis
claimConclusion Ultrasound-guided hyaluronic acid injection and supervised rehabilitation produced comparable and clinically meaningful improvements in pain, function, and shoulder mobility in frozen-phase adhesive capsulitis.
evidence level2
citationChang CY (2026)
sourceEfficacy of ultrasound-guided intra-articular hyaluronic acid injection in the management of adhesive capsulitis: a randomized controlled trial.
topicHyaluronic Acid Joint Pain Meta-Analysis
claimObjective To compare the efficacy and safety of ultrasound-guided intra-articular hyaluronic acid injection versus supervised rehabilitation in patients with frozen-phase adhesive capsulitis.
evidence level2
citationChang CY (2026)
sourceEfficacy of ultrasound-guided intra-articular hyaluronic acid injection in the management of adhesive capsulitis: a randomized controlled trial.
topicHyaluronic Acid Joint Pain Meta-Analysis
claimDesign Single-center, parallel-group, randomized controlled trial with 26-week follow-up.
evidence level2
citationChang CY (2026)
sourceEfficacy of ultrasound-guided intra-articular hyaluronic acid injection in the management of adhesive capsulitis: a randomized controlled trial.
topicHyaluronic Acid Joint Pain Meta-Analysis
claimTo ensure a robust synthesis of evidence, we conducted a systematic search of PubMed, Embase, and Web of Science (2020-2025) for high-quality clinical trials, meta-analyses, and guidelines.
evidence level4
citationWang H (2026)
sourceEvolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions.
topicHyaluronic Acid Joint Pain Meta-Analysis
claimThis narrative review evaluates the clinical transition from reactive, surgery-centric models to a proactive, integrated framework to mitigate the profound socioeconomic burden and functional decline associated with the disease.
evidence level4
citationWang H (2026)
sourceEvolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions.
topicHyaluronic Acid Joint Pain Meta-Analysis
claimWe synthesized evidence across non-pharmacological rehabilitation, pharmacotherapy, and advanced joint-preserving surgeries, emphasizing optimal intervention windows and stage-specific mechanobiological requirements.
evidence level4
citationWang H (2026)
sourceEvolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions.
topicHyaluronic Acid Joint Pain Meta-Analysis
claimKnee osteoarthritis (KOA) is a primary driver of global disability, currently affecting over 365 million adults, with projections suggesting a 74.9% increase by 2050.
evidence level4
citationWang H (2026)
sourceEvolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions.