Structured evidence table for Hyaluronic Acid Joint Comfort Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Hyaluronic Acid Joint Comfort Meta-Analysis | The majority of the literature suggests that IAHA has a positive safety profile despite a few meta-analyses suggesting an increased risk of serious adverse effects. | 2 | Fuggle N (2026) | Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach. |
| Hyaluronic Acid Joint Comfort Meta-Analysis | Specific to IAHA, patients seek minimally invasive, lower-risk, and non-steroidal options with at least moderate efficacy and advantageous safety profiles. | 2 | Fuggle N (2026) | Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach. |
| Hyaluronic Acid Joint Comfort Meta-Analysis | Hyaluronic acid (HA) is a linear polysaccharide which occurs naturally as a constituent of synovial fluid. | 2 | Fuggle N (2026) | Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach. |
| Hyaluronic Acid Joint Comfort Meta-Analysis | The HA concentration in the joint decreases inexorably during the progression of knee osteoarthritis (OA) and so, for nearly five decades, HA has been trialled and used in the treatment of knee OA. | 2 | Fuggle N (2026) | Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach. |
| Hyaluronic Acid Joint Comfort Meta-Analysis | Targeted searches of Medical Literature Analysis and Retrieval System Online (MEDLINE) (via PubMed), the Cochrane Library, and guideline repositories (American Academy of Orthopaedic Surgeons (AAOS)/American Shoulder and Elbow Surgeons (ASES)/American Physical Therapy Association (APTA)/American College of Rheumatology (ACR)) were performed from 2010 to October 2025. | 4 | Vargas-Figueroa RA (2025) | Current Non-operative Management of Shoulder Pathologies: A Narrative Review. |
| Hyaluronic Acid Joint Comfort Meta-Analysis | In GHOA, individualized range of motion (ROM) maintenance and strengthening, activity adaptation, and time-limited injections (corticosteroid; hyaluronic acid with variable evidence) dominate care; platelet-rich plasma remains investigational. | 4 | Vargas-Figueroa RA (2025) | Current Non-operative Management of Shoulder Pathologies: A Narrative Review. |
| Hyaluronic Acid Joint Comfort Meta-Analysis | Shoulder disorders, including rotator cuff-related pain, adhesive capsulitis, impingement, glenohumeral osteoarthritis (GHOA), acromioclavicular (AC) pathology, instability, and biceps/superior labrum anterior to posterior (SLAP) lesions, are prevalent causes of pain, disability, and healthcare utilization. | 4 | Vargas-Figueroa RA (2025) | Current Non-operative Management of Shoulder Pathologies: A Narrative Review. |
| Hyaluronic Acid Joint Comfort Meta-Analysis | Contemporary care emphasizes non-operative strategies as first-line management, with surgery reserved for refractory symptoms or specific structural indications. | 4 | Vargas-Figueroa RA (2025) | Current Non-operative Management of Shoulder Pathologies: A Narrative Review. |
Source documents