topic5-HTP Sleep Meta-Analysis
claimThe certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation tool.
evidence level1
citationLi J (2025)
sourceSleep disorders in Parkinson's disease: evaluating pharmacological treatments through systematic review and meta-analysis.
topic5-HTP Sleep Meta-Analysis
claimSleep disorders are the most common non-motor symptoms in patients with Parkinson’s disease (PD) and can significantly impact quality of life.
evidence level1
citationLi J (2025)
sourceSleep disorders in Parkinson's disease: evaluating pharmacological treatments through systematic review and meta-analysis.
topic5-HTP Sleep Meta-Analysis
claimHowever, the pharmacological treatments for sleep disorders in patients with PD remain controversial.
evidence level1
citationLi J (2025)
sourceSleep disorders in Parkinson's disease: evaluating pharmacological treatments through systematic review and meta-analysis.
topic5-HTP Sleep Meta-Analysis
claimBackground In patients with Inflammatory Bowel Disease (IBD), fatigue is a debilitating problem and may be associated with sleep disturbance, anxiety, depression, anemia, use of systemic steroids and active phase of the disease.
evidence level4
citationMorais T (2026)
sourcePHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.
topic5-HTP Sleep Meta-Analysis
claimIn addition, fatigue also affects the working conditions of these patients, as it is associated with absenteeism and is a reason for time off work, surpassing medical appointments and abdominal pain.
evidence level4
citationMorais T (2026)
sourcePHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.
topic5-HTP Sleep Meta-Analysis
claimFatigue symptoms have been reduced with the use of vedolizumab, upadacitinib and modafinil.
evidence level4
citationMorais T (2026)
sourcePHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.