Is L-Theanine Sleep Latency Randomized Trial safe?

The current Migaku evidence database contains 2 reusable source documents for L-Theanine Sleep Latency Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Results : The mean THI score decreased from 40.8 at baseline to 30.9 at the end of the study ( p = 0.012), and the percentage of patients with THI grade 1 (no handicap) increased from 3.3% to 20%. [Cepeda Uceta M (2026); evidence level 3] - A decrease in the mean frequency of tinnitus from 2417.4 Hz to 1603.3 Hz ( p = 0.519) was found. [Cepeda Uceta M (2026); evidence level 3] - Conclusions : The administration of a natural-based dietary supplement composed of L-theanine, Ginkgo biloba , melatonin, GABA, zinc, selenium, and group B vitamins during 90 days in patients with tinnitus was associated with a significant increase in QoL by reducing tinnitus-associated handicap and anxiety. [Cepeda Uceta M (2026); evidence level 3] - Background/Objectives : The objective of the study was to assess the benefits on quality of life (QoL) of a natural-based dietary supplement in patients with tinnitus. [Cepeda Uceta M (2026); evidence level 3] - Sleep is a complex biological process whose evolutionary purpose has remained equivocal for quite some time.More recently, however, compelling evidence has emerged, leading to recognition of the numerous metabolic and physiological functions sleep contributes to and actively supports. [Conti Federica (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.