Is Citrulline Exercise Performance Randomized Trial safe?

The current Migaku evidence database contains 2 reusable source documents for Citrulline Exercise Performance Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Strategies that support repeated high-intensity sprint performance are of considerable interest in competitive sprinting and team sports; however, evidence regarding acute citrulline malate (CM) supplementation during recovery intervals remains limited. [Yamanaka R (2026); evidence level 2] - This study examined the effects of acute CM supplementation on repeated 100 m sprint performance and rating of perceived exertion (RPE) in trained sprinters. [Yamanaka R (2026); evidence level 2] - Through its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,–). [Uçar Halil (2026); evidence level 4] - However, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established. [Uçar Halil (2026); evidence level 4] - No significant sequence effect was detected (= 1.08,= 0.393, ηp= 0.213), and no significant period × sequence interaction was observed (= 1.04,= 0.430, ηp= 0.206), indicating no statistically significant evidence of meaningful carryover effects and supporting the adequacy of the 72-h washout period. [Uçar Halil (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.