Does Citrulline Blood Pressure Meta-Analysis work?

The current Migaku evidence database contains 2 reusable source documents for Citrulline Blood Pressure Meta-Analysis. This answer focuses on strength of evidence and what the studies can or cannot prove. - The primary objective of this systematic review and meta-analysis is to investigate whether L-citrulline supplementation can counteract the adverse effects of cold environments on individual blood pressure (BP), providing scientific evidence for the clinical development and application of L-citrulline as a cardiovascular protective nutritional supplement. [Luo P (2026); evidence level 1] - The Cochrane Risk of Bias tool and JADAD scoring scale were used to assess risk of bias and literature quality of the included randomized controlled trials (RCTs). [Luo P (2026); evidence level 1] - Results indicate that L-citrulline intake significantly reduced cold-induced SBP (-9.28 mmHg [95% CI: -10.66 to -7.90], p p = 0.01). [Luo P (2026); evidence level 1] - A comprehensive search was conducted across four electronic databases: PubMed, Cochrane Library, Embase, and Web of Science. [Luo P (2026); evidence level 1] - Due to the complex and multifactorial nature of these pregnancy-related complications and the potential risk of any intervention on the developing fetus to date, no effective therapeutic approaches for prevention or treatment exist, besides supportive treatments aspirin, antihypertensives, magnesium sulfate and timely delivery. [van Kammen Caren (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.