topicL-Citrulline Blood Pressure Meta-Analysis
claimThe primary objective of this systematic review and meta-analysis is to investigate whether L-citrulline supplementation can counteract the adverse effects of cold environments on individual blood pressure (BP), providing scientific evidence for the clinical development and application of L-citrulline as a cardiovascular protective nutritional supplement.
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicL-Citrulline Blood Pressure Meta-Analysis
claimThe Cochrane Risk of Bias tool and JADAD scoring scale were used to assess risk of bias and literature quality of the included randomized controlled trials (RCTs).
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicL-Citrulline Blood Pressure Meta-Analysis
claimResults indicate that L-citrulline intake significantly reduced cold-induced SBP (-9.28 mmHg [95% CI: -10.66 to -7.90], p p = 0.01).
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicL-Citrulline Blood Pressure Meta-Analysis
claimA comprehensive search was conducted across four electronic databases: PubMed, Cochrane Library, Embase, and Web of Science.
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicL-Citrulline Blood Pressure Meta-Analysis
claimLiposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction.
evidence level4
citationvan Kammen C (2026)
sourceLiposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction.