evidence table

L-Citrulline Blood Pressure Cold Environments Meta-Analysis Evidence Table

Structured evidence table for L-Citrulline Blood Pressure Cold Environments Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
L-Citrulline Blood Pressure Cold Environments Meta-AnalysisThe primary objective of this systematic review and meta-analysis is to investigate whether L-citrulline supplementation can counteract the adverse effects of cold environments on individual blood pressure (BP), providing scientific evidence for the clinical development and application of L-citrulline as a cardiovascular protective nutritional supplement.1Luo P (2026)Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
L-Citrulline Blood Pressure Cold Environments Meta-AnalysisThe Cochrane Risk of Bias tool and JADAD scoring scale were used to assess risk of bias and literature quality of the included randomized controlled trials (RCTs).1Luo P (2026)Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
L-Citrulline Blood Pressure Cold Environments Meta-AnalysisResults indicate that L-citrulline intake significantly reduced cold-induced SBP (-9.28 mmHg [95% CI: -10.66 to -7.90], p p = 0.01).1Luo P (2026)Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
L-Citrulline Blood Pressure Cold Environments Meta-AnalysisA comprehensive search was conducted across four electronic databases: PubMed, Cochrane Library, Embase, and Web of Science.1Luo P (2026)Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
L-Citrulline Blood Pressure Cold Environments Meta-AnalysisWhile a gradual decline in testosterone with advancing age is well recognized—most notably in men aged 70–80 years, and progressively in women during the premenopausal period with a stabilization or a modest increase after menopause [,]—cumulative evidence has documented an additional, age-independent decline in men.3Fraile-Martínez Óscar (2026)Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
L-Citrulline Blood Pressure Cold Environments Meta-AnalysisFrom a medical perspective, low testosterone levels (clinically diagnosed as hypogonadism) are strongly associated with various chronic maladies including metabolic syndrome, cardiovascular disease and overall mortality [,,,,].3Fraile-Martínez Óscar (2026)Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
L-Citrulline Blood Pressure Cold Environments Meta-AnalysisPsychologically and socially, low testosterone levels are linked to increased rates of depression, anxiety, reduced motivation, lower quality of life, and impaired social behaviors such as competitiveness and engagement [,,,,].3Fraile-Martínez Óscar (2026)Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
L-Citrulline Blood Pressure Cold Environments Meta-Analysis1 2 3 4 5 Testosterone is one of the most extensively studied hormones in endocrinology, yet its clinical significance continues to evolve as our understanding of its complex physiological roles deepens.3Fraile-Martínez Óscar (2026)Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
topicL-Citrulline Blood Pressure Cold Environments Meta-Analysis
claimThe primary objective of this systematic review and meta-analysis is to investigate whether L-citrulline supplementation can counteract the adverse effects of cold environments on individual blood pressure (BP), providing scientific evidence for the clinical development and application of L-citrulline as a cardiovascular protective nutritional supplement.
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicL-Citrulline Blood Pressure Cold Environments Meta-Analysis
claimThe Cochrane Risk of Bias tool and JADAD scoring scale were used to assess risk of bias and literature quality of the included randomized controlled trials (RCTs).
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicL-Citrulline Blood Pressure Cold Environments Meta-Analysis
claimResults indicate that L-citrulline intake significantly reduced cold-induced SBP (-9.28 mmHg [95% CI: -10.66 to -7.90], p p = 0.01).
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicL-Citrulline Blood Pressure Cold Environments Meta-Analysis
claimA comprehensive search was conducted across four electronic databases: PubMed, Cochrane Library, Embase, and Web of Science.
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicL-Citrulline Blood Pressure Cold Environments Meta-Analysis
claimWhile a gradual decline in testosterone with advancing age is well recognized—most notably in men aged 70–80 years, and progressively in women during the premenopausal period with a stabilization or a modest increase after menopause [,]—cumulative evidence has documented an additional, age-independent decline in men.
evidence level3
citationFraile-Martínez Óscar (2026)
sourceUnderstanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
topicL-Citrulline Blood Pressure Cold Environments Meta-Analysis
claimFrom a medical perspective, low testosterone levels (clinically diagnosed as hypogonadism) are strongly associated with various chronic maladies including metabolic syndrome, cardiovascular disease and overall mortality [,,,,].
evidence level3
citationFraile-Martínez Óscar (2026)
sourceUnderstanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
topicL-Citrulline Blood Pressure Cold Environments Meta-Analysis
claimPsychologically and socially, low testosterone levels are linked to increased rates of depression, anxiety, reduced motivation, lower quality of life, and impaired social behaviors such as competitiveness and engagement [,,,,].
evidence level3
citationFraile-Martínez Óscar (2026)
sourceUnderstanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
topicL-Citrulline Blood Pressure Cold Environments Meta-Analysis
claim1 2 3 4 5 Testosterone is one of the most extensively studied hormones in endocrinology, yet its clinical significance continues to evolve as our understanding of its complex physiological roles deepens.
evidence level3
citationFraile-Martínez Óscar (2026)
sourceUnderstanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives

Learn next

Related evidence and supplement guides

GuideL-citrulline Blood Pressure Cold Environments Meta-analysis: What the Evidence SaysL-citrulline Blood Pressure Cold Environments Meta-analysis has 2 source documents in the curren...GuideL-citrulline Blood Pressure Meta-analysis: What the Evidence SaysL-citrulline Blood Pressure Meta-analysis has 2 source documents in the current Migaku evidence...GuideL-citrulline Blood Pressure Randomized Trial: What the Evidence SaysL-citrulline Blood Pressure Randomized Trial has 1 source documents in the current Migaku eviden...GuideCitrulline Blood Pressure Randomized Trial: What the Evidence SaysCitrulline Blood Pressure Randomized Trial has 2 source documents in the current Migaku evidence...AnswerDoes L-Citrulline Blood Pressure Cold Environments Meta-Analysis work?L-Citrulline Blood Pressure Cold Environments Meta-Analysis has evidence relevant to strength of...AnswerIs L-Citrulline Blood Pressure Cold Environments Meta-Analysis safe?L-Citrulline Blood Pressure Cold Environments Meta-Analysis has evidence relevant to safety, lim...AnswerWhat does the evidence say about L-Citrulline Blood Pressure Cold Environments Meta-Analysis?L-Citrulline Blood Pressure Cold Environments Meta-Analysis has evidence relevant to benefits, u...AnswerDoes L-Citrulline Blood Pressure Meta-Analysis work?L-Citrulline Blood Pressure Meta-Analysis has evidence relevant to strength of evidence and what...

Source documents

  1. Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
  2. Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives