topicCitrulline Blood Pressure Meta-Analysis
claimThe primary objective of this systematic review and meta-analysis is to investigate whether L-citrulline supplementation can counteract the adverse effects of cold environments on individual blood pressure (BP), providing scientific evidence for the clinical development and application of L-citrulline as a cardiovascular protective nutritional supplement.
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicCitrulline Blood Pressure Meta-Analysis
claimThe Cochrane Risk of Bias tool and JADAD scoring scale were used to assess risk of bias and literature quality of the included randomized controlled trials (RCTs).
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicCitrulline Blood Pressure Meta-Analysis
claimResults indicate that L-citrulline intake significantly reduced cold-induced SBP (-9.28 mmHg [95% CI: -10.66 to -7.90], p p = 0.01).
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicCitrulline Blood Pressure Meta-Analysis
claimA comprehensive search was conducted across four electronic databases: PubMed, Cochrane Library, Embase, and Web of Science.
evidence level1
citationLuo P (2026)
sourceEffect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicCitrulline Blood Pressure Meta-Analysis
claimDue to the complex and multifactorial nature of these pregnancy-related complications and the potential risk of any intervention on the developing fetus to date, no effective therapeutic approaches for prevention or treatment exist, besides supportive treatments aspirin, antihypertensives, magnesium sulfate and timely delivery.
evidence level4
citationvan Kammen Caren (2026)
sourceLiposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction
topicCitrulline Blood Pressure Meta-Analysis
claimReduced nitric oxide (NO) bioavailability plays a key role in maintaining vascular function and placental health.
evidence level4
citationvan Kammen Caren (2026)
sourceLiposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction
topicCitrulline Blood Pressure Meta-Analysis
claimReduced levels of NO contribute to the pathophysiology of PE and FGR by causing endothelial dysfunction and impaired placental perfusion, compromising nutrient supply.
evidence level4
citationvan Kammen Caren (2026)
sourceLiposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction
topicCitrulline Blood Pressure Meta-Analysis
claimPreeclampsia (PE) and fetal growth restriction (FGR) have significant implications for maternal and fetal health.
evidence level4
citationvan Kammen Caren (2026)
sourceLiposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction