evidence table
Vitamin K Bone Health Meta-Analysis Evidence Table
Structured evidence table for Vitamin K Bone Health Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Vitamin K Bone Health Meta-Analysis | Genetic variants in VKORC1 may influence bone mineral density (BMD) and osteoporosis risk. | 1 | Vesa ŞC (2026) | Association Between <i>VKORC1</i> Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis. |
| Vitamin K Bone Health Meta-Analysis | The overall effect of VKORC1 risk alleles on osteopenia/osteoporosis was significant with a p = 0.041 (fixed effects OR = 1.16, 95% CI = 1.01-1.35). | 1 | Vesa ŞC (2026) | Association Between <i>VKORC1</i> Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis. |
| Vitamin K Bone Health Meta-Analysis | The current body of evidence requires further studies to elucidate whether VKORC1 polymorphisms have a clinically meaningful role in bone health. | 1 | Vesa ŞC (2026) | Association Between <i>VKORC1</i> Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis. |
| Vitamin K Bone Health Meta-Analysis | Background and Objectives: The vitamin K epoxide reductase complex subunit 1 (VKORC1) plays a central role in the vitamin K cycle, which is essential for γ-carboxylation of multiple bone-related proteins. | 1 | Vesa ŞC (2026) | Association Between <i>VKORC1</i> Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis. |
| Vitamin K Bone Health Meta-Analysis | Accumulating evidence links this condition to impaired glucose [,,,,] and calcium metabolism [,], highlighting the need to better define VK’s roles within the endocrine regulatory pathways. | 3 | Matuszewski Wojciech (2026) | Vitamin K as an Endocrine Modulator: Mechanistic Links to Glucose Metabolism and Beyond |
| Vitamin K Bone Health Meta-Analysis | In this narrative review, we integrate the current evidence on VK within the context of the endocrine system, with primary emphasis on glucose metabolism. | 3 | Matuszewski Wojciech (2026) | Vitamin K as an Endocrine Modulator: Mechanistic Links to Glucose Metabolism and Beyond |
| Vitamin K Bone Health Meta-Analysis | Initial broad searches were conducted to identify endocrine pathways potentially linked to VK, and search terms were subsequently refined based on the availability and relevance of mechanistic and clinical evidence. | 3 | Matuszewski Wojciech (2026) | Vitamin K as an Endocrine Modulator: Mechanistic Links to Glucose Metabolism and Beyond |
| Vitamin K Bone Health Meta-Analysis | 1 2 3 4 5 6 7 8 9 10 11 9 12 13 14 15 9 10 11 12 16 17 18 19 20 21 4 7 Vitamin K (VK) is best known for its essential role in blood coagulation but is increasingly recognized as a contributor to a range of extrahepatic processes, including glucose regulation and insulin sensitivity [,], bone and mineral metabolism [,], immune and inflammatory pathways [,], and vascular health [,]. | 3 | Matuszewski Wojciech (2026) | Vitamin K as an Endocrine Modulator: Mechanistic Links to Glucose Metabolism and Beyond |
Source documents