topicVitamin C Skin Randomized Trial
claimIt creates microchannels in the skin with fine needles and may help regulate increased melanocyte stimulation and vascular abnormalities [,].
evidence level3
citationDhaliwal Sharon (2026)
sourceExploring the Effectiveness, Tolerability, and Safety of the Adjunctive Use of Microneedling With Tranexamic Acid in the Treatment of Melasma
topicVitamin C Skin Randomized Trial
claimIts primary mechanism is microtrauma induced activation of wound healing pathways, resulting in increased collagen and elastin production and epidermal thickening [,,].
evidence level3
citationDhaliwal Sharon (2026)
sourceExploring the Effectiveness, Tolerability, and Safety of the Adjunctive Use of Microneedling With Tranexamic Acid in the Treatment of Melasma
topicVitamin C Skin Randomized Trial
claimThis scoping review aims to consolidate and summarize the available clinical evidence to support informed and individualized treatment decision making in melasma management.
evidence level3
citationDhaliwal Sharon (2026)
sourceExploring the Effectiveness, Tolerability, and Safety of the Adjunctive Use of Microneedling With Tranexamic Acid in the Treatment of Melasma
topicVitamin C Skin Randomized Trial
claim1 2 3 4 1 5 5 6 7 Melasma is a skin disorder that manifests with patches of brownish‐gray hyperpigmentation, commonly on sun‐exposed areas of the face.
evidence level3
citationDhaliwal Sharon (2026)
sourceExploring the Effectiveness, Tolerability, and Safety of the Adjunctive Use of Microneedling With Tranexamic Acid in the Treatment of Melasma