topicVitamin C Skin Photoaging Randomized Trial
claimAccumulation of damage leads to increased reactive oxygen species and changes the properties and quantity of matrix proteins [].
evidence level2
citationAfzal Laila (2026)
sourceProspective, Randomized, Double‐Blind, Placebo‐Controlled Study of an Oral Antioxidant‐Rich Synbiotic Supplement on Skin Health and Photoaging
topicVitamin C Skin Photoaging Randomized Trial
claimReduced collagen has been shown to contribute to skin aging and is what contributes to wrinkle formation [].
evidence level2
citationAfzal Laila (2026)
sourceProspective, Randomized, Double‐Blind, Placebo‐Controlled Study of an Oral Antioxidant‐Rich Synbiotic Supplement on Skin Health and Photoaging
topicVitamin C Skin Photoaging Randomized Trial
claimAstaxanthin (ASX) is an α‐hydroxy‐ketocarotenoid found in numerous bacterial species, microalgae, and marine animals, including shrimp, crab, and salmon [,].
evidence level2
citationAfzal Laila (2026)
sourceProspective, Randomized, Double‐Blind, Placebo‐Controlled Study of an Oral Antioxidant‐Rich Synbiotic Supplement on Skin Health and Photoaging
topicVitamin C Skin Photoaging Randomized Trial
claim1 1 2 3 4 4 3 4 Human skin is a complex organ that covers the entire human body.
evidence level2
citationAfzal Laila (2026)
sourceProspective, Randomized, Double‐Blind, Placebo‐Controlled Study of an Oral Antioxidant‐Rich Synbiotic Supplement on Skin Health and Photoaging
topicVitamin C Skin Photoaging Randomized Trial
claimWe describe features of photoaging across skin types, including the increased susceptibility to developing pigmentary alterations in skin of color, along with the role of photoprotection in preventing them.
evidence level4
citationTsai J (2026)
sourcePhotoaging: Update on Pathogenesis, Prevention, and Treatment.
topicVitamin C Skin Photoaging Randomized Trial
claimSkin aging is driven by the intrinsic aging process, onto which extrinsic environmental stimuli exert damaging effects.
evidence level4
citationTsai J (2026)
sourcePhotoaging: Update on Pathogenesis, Prevention, and Treatment.
topicVitamin C Skin Photoaging Randomized Trial
claimAmongst the external factors, chronic sun exposure contributes the most, and that effect is recognized as photoaging.
evidence level4
citationTsai J (2026)
sourcePhotoaging: Update on Pathogenesis, Prevention, and Treatment.