topicVitamin C Skin Aging Randomized Trial
claimIn recent decades, accumulating evidence has established that four interrelated biological processes, including skin glycation, oxidation, carbonylation, and excessive inflammatory factor release, act as core contributors to the pathogenesis of skin aging and pigmentation [,].
evidence level4
citationZi Yusha (2026)
sourceStudy on the Multiple Efficacies of Vitamin C Serum in Anti‐Glycation, Anti‐Carbonylation, Antioxidation, and Anti‐Inflammation of Human Skin Based on In Vivo Tests
topicVitamin C Skin Aging Randomized Trial
claimThese changes ultimately result in visible signs of aging, including skin sagging, fine lines, and dullness.
evidence level4
citationZi Yusha (2026)
sourceStudy on the Multiple Efficacies of Vitamin C Serum in Anti‐Glycation, Anti‐Carbonylation, Antioxidation, and Anti‐Inflammation of Human Skin Based on In Vivo Tests
topicVitamin C Skin Aging Randomized Trial
claimCarbonylated proteins lose their biological function and accumulate in the stratum corneum, leading to increased skin roughness, dryness, and a yellow complexion [].
evidence level4
citationZi Yusha (2026)
sourceStudy on the Multiple Efficacies of Vitamin C Serum in Anti‐Glycation, Anti‐Carbonylation, Antioxidation, and Anti‐Inflammation of Human Skin Based on In Vivo Tests
topicVitamin C Skin Aging Randomized Trial
claim1 2 Skin aging and pigmentation represent two of the most common dermatological concerns among adult populations, with profound impacts on individuals' aesthetic satisfaction and psychological well‐being.
evidence level4
citationZi Yusha (2026)
sourceStudy on the Multiple Efficacies of Vitamin C Serum in Anti‐Glycation, Anti‐Carbonylation, Antioxidation, and Anti‐Inflammation of Human Skin Based on In Vivo Tests
topicVitamin C Skin Aging Randomized Trial
claimCollagen, along with antioxidants such as curcumin and glutathione, have gained increased utilization/awareness in recent years, providing dermal health benefits especially in women who experience declining or loss of estrogen with aging.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicVitamin C Skin Aging Randomized Trial
claimThe evidence of oral collagen as a nutraceutical is robust for improving several aspects of dermal health.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicVitamin C Skin Aging Randomized Trial
claimFor example, the epidermis is without a blood supply and does not have the same circulation and nutrient delivery found in the dermis [–].
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicVitamin C Skin Aging Randomized Trial
claimThe present narrative review is an extension of a larger project that covered polyphenols and phytoestrogens.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review