evidence table

Vitamin C Collagen Synthesis Meta-Analysis Evidence Table

Name: Vitamin C Collagen Synthesis Meta-Analysis Evidence Table
Creator: Migaku
License: https://creativecommons.org/licenses/by/4.0/

Structured evidence table for Vitamin C Collagen Synthesis Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Vitamin C Collagen Synthesis Meta-Analysis	Vitamin D was associated with significantly lower risks of pigmentation changes (RR = 0.23; 95% CI 0.07 to 0.78; p = 0.018) and skin atrophy (RR = 0.51; 95% CI 0.32 to 0.82; p = 0.006), with no significant differences in pain, erythema, telangiectasia, or blister formation.	1	Jiang D (2026)	Intralesional vitamin D versus triamcinolone acetonide for the treatment of keloids: a systematic review and meta-analysis of randomized controlled trials.
Vitamin C Collagen Synthesis Meta-Analysis	While TAC appeared more effective for scar regression and lesion flattening, vitamin D was associated with a more favorable safety profile, particularly regarding skin atrophy and dyspigmentation.	1	Jiang D (2026)	Intralesional vitamin D versus triamcinolone acetonide for the treatment of keloids: a systematic review and meta-analysis of randomized controlled trials.
Vitamin C Collagen Synthesis Meta-Analysis	Vitamin D may be considered in selected patients who are particularly concerned about steroid-related adverse effects or lesions located in cosmetically sensitive areas, although these findings should be interpreted cautiously given the limited evidence base.	1	Jiang D (2026)	Intralesional vitamin D versus triamcinolone acetonide for the treatment of keloids: a systematic review and meta-analysis of randomized controlled trials.
Vitamin C Collagen Synthesis Meta-Analysis	Intralesional triamcinolone acetonide (TAC) remains the standard nonsurgical treatment for keloids but is limited by steroid-related adverse effects.	1	Jiang D (2026)	Intralesional vitamin D versus triamcinolone acetonide for the treatment of keloids: a systematic review and meta-analysis of randomized controlled trials.
Vitamin C Collagen Synthesis Meta-Analysis	To investigate this, a systematic review was conducted to assess clinical evidence linking vitamin C status, via supplementation or biochemical deficiency, to DFU prevalence and healing outcomes.	1	Saad MA (2026)	Vitamin C Supplementation Accelerates Healing in Diabetic Foot Ulcers: Insights From a Systematic Review of Clinical Evidence.
Vitamin C Collagen Synthesis Meta-Analysis	The quality of evidence was subsequently evaluated using the Cochrane RoB 2.0 tool for randomized controlled trials (RCTs) and the Newcastle-Ottawa Scale for observational studies.	1	Saad MA (2026)	Vitamin C Supplementation Accelerates Healing in Diabetic Foot Ulcers: Insights From a Systematic Review of Clinical Evidence.
Vitamin C Collagen Synthesis Meta-Analysis	Vitamin C supplementation (500-1000 mg/day) significantly enhanced DFU healing outcomes in all four RCTs, with improved wound closure, reduced ulcer size, and faster recovery compared with control groups.	1	Saad MA (2026)	Vitamin C Supplementation Accelerates Healing in Diabetic Foot Ulcers: Insights From a Systematic Review of Clinical Evidence.
Vitamin C Collagen Synthesis Meta-Analysis	Diabetic foot ulcers (DFUs) persist as a predominant clinical challenge, constituting the primary etiological factor in the pathway to lower-extremity amputation and a significant source of comorbidity and mortality among individuals with diabetes mellitus.	1	Saad MA (2026)	Vitamin C Supplementation Accelerates Healing in Diabetic Foot Ulcers: Insights From a Systematic Review of Clinical Evidence.