topicMelissa Sleep Quality Meta-Analysis
claimResults HME significantly reduced sleep onset latency and prolonged total sleep time.
evidence level4
citationJee HJ (2026)
sourceHypnotic Effects of <i>Hypericum perforatum</i> L. and <i>Melissa officinalis</i> L. Through Adenosine and Melatonin Receptors.
topicMelissa Sleep Quality Meta-Analysis
claimAt the molecular level, HME increased cortical mRNA expression levels of adenosine A 1 receptor, adenosine A 2A receptor, melatonin receptor 1, and melatonin receptor 2.
evidence level4
citationJee HJ (2026)
sourceHypnotic Effects of <i>Hypericum perforatum</i> L. and <i>Melissa officinalis</i> L. Through Adenosine and Melatonin Receptors.
topicMelissa Sleep Quality Meta-Analysis
claimBackground Sleep disorders, particularly insomnia, represent a major public health concern, while currently available hypnotic drugs are often limited by adverse effects and poor long-term tolerability.
evidence level4
citationJee HJ (2026)
sourceHypnotic Effects of <i>Hypericum perforatum</i> L. and <i>Melissa officinalis</i> L. Through Adenosine and Melatonin Receptors.
topicMelissa Sleep Quality Meta-Analysis
claimMethods In this study, we investigated the sleep-promoting effects of a mixture of Hypericum perforatum L.
evidence level4
citationJee HJ (2026)
sourceHypnotic Effects of <i>Hypericum perforatum</i> L. and <i>Melissa officinalis</i> L. Through Adenosine and Melatonin Receptors.
topicMelissa Sleep Quality Meta-Analysis
claimResults PSQI scores significantly improved over time ( P P P P Discussion MOP, particularly at 400 mg/day, confirmed to significantly improve sleep and life quality, mood, and overall mental well-being.
evidence level4
citationRondanelli M (2026)
sourceMelissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress.
topicMelissa Sleep Quality Meta-Analysis
claimConclusion These findings support and extend the health benefits of MOP as a well-tolerated, safe natural approach in a dose-dependent frame to managing sleep quality and emotional distress.
evidence level4
citationRondanelli M (2026)
sourceMelissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress.
topicMelissa Sleep Quality Meta-Analysis
claim(lemon balm) is a botanical support widely used for its calming and sleep-promoting properties.
evidence level4
citationRondanelli M (2026)
sourceMelissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress.
topicMelissa Sleep Quality Meta-Analysis
claimObjective To evaluate the impact of daily supplementation with Melissa phospholipids (MOP) at 200 or 400 mg for 3 weeks on sleep quality and psychological well-being in adults with emotional distress and poor sleep quality.
evidence level4
citationRondanelli M (2026)
sourceMelissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress.