topicMagnesium Glycinate Sleep Quality Randomized Trial
claimThis case series presents outcomes of the first 51 patients who participated in one such program and aims to add to preliminary evidence regarding the efficacy of a personalized multimodal integrative functional medicine approach to cognitive decline in the context of prior uncontrolled and ongoing controlled trials.
evidence level4
citationKogan Mikhail (2026)
sourceThe Integrative Personalized Functional Medicine Approach to Reverse Cognitive Decline: Academic Experience of the First 51 Patients Case Series
topicMagnesium Glycinate Sleep Quality Randomized Trial
claimManagement of vascular risk factors (hypertension, hyperlipidemia, diabetes), tobacco and alcohol counseling, and hearing evaluation were conducted through participants’ primary clinicians, consistent with standard dementia prevention guidelines.
evidence level4
citationKogan Mikhail (2026)
sourceThe Integrative Personalized Functional Medicine Approach to Reverse Cognitive Decline: Academic Experience of the First 51 Patients Case Series
topicMagnesium Glycinate Sleep Quality Randomized Trial
claimAs shown in, participants in the “improved” group were older and more likely to carry at least one APOE4 allele, whereas those in the “progressed” group were younger and started with lower baseline MoCA scores.
evidence level4
citationKogan Mikhail (2026)
sourceThe Integrative Personalized Functional Medicine Approach to Reverse Cognitive Decline: Academic Experience of the First 51 Patients Case Series
topicMagnesium Glycinate Sleep Quality Randomized Trial
claim1 5 - 1 5 - Alzheimer’s disease (AD) and related dementias are significant public health challenges with limited treatment options.
evidence level4
citationKogan Mikhail (2026)
sourceThe Integrative Personalized Functional Medicine Approach to Reverse Cognitive Decline: Academic Experience of the First 51 Patients Case Series