evidence table

Magnesium Glycinate Sleep Onset Meta-Analysis Evidence Table

Structured evidence table for Magnesium Glycinate Sleep Onset Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Magnesium Glycinate Sleep Onset Meta-AnalysisTemporomandibular disorders (TMDs) are among the most common causes of chronic orofacial pain, with myalgia of the masticatory muscles being a major.Patients frequently present with persistent aching pain, muscle tenderness, and restricted jaw function, all of which significantly impair quality of life.While existing treatments are mainly symptomatic,emerging evidence suggests a role for electrolyte modulation.1Patil Shankargouda (2026)The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Magnesium Glycinate Sleep Onset Meta-AnalysisNotably, a recent randomized controlled trial demonstrated that local magnesium sulphate injection into the masseter muscle significantly reduced pain intensity and improved function in TMD myalgia, providing a direct clinical link between electrolyte biology and orofacial pain.This observation highlights the potential for broader exploration of electrolyte-based interventions in TMD.1Patil Shankargouda (2026)The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Magnesium Glycinate Sleep Onset Meta-AnalysisMuscle cramps – whether idiopathic nocturnal, pregnancy-associated, or exercise-induced – arise from abnormal neuromuscular excitability,impaired ion-channel regulation,and nociceptor sensitization.These same processes are also implicated in TMD myalgia,suggesting that insights from cramp interventions may inform novel strategies for managing orofacial muscle pain.1Patil Shankargouda (2026)The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Magnesium Glycinate Sleep Onset Meta-AnalysisAssociated symptoms may include nausea, vomiting, photophobia, and phonophobia [].3Rodriguez Juan Pablo (2025)Magnesium supplementation for migraine prophylaxis
Magnesium Glycinate Sleep Onset Meta-AnalysisHormonal shifts during breastfeeding might also affect migraine occurrence, although the evidence is not definitive [].3Rodriguez Juan Pablo (2025)Magnesium supplementation for migraine prophylaxis
Magnesium Glycinate Sleep Onset Meta-AnalysisSimilarly, another systematic review found a 7.7% migraine prevalence in this age group, with girls experiencing migraine more often than boys [].3Rodriguez Juan Pablo (2025)Magnesium supplementation for migraine prophylaxis
Magnesium Glycinate Sleep Onset Meta-AnalysisSecondary headaches are triggered by an existing medical problem, such as issues with blood vessels, tumors, infections, or changes in pressure or volume within the skull.3Rodriguez Juan Pablo (2025)Magnesium supplementation for migraine prophylaxis
topicMagnesium Glycinate Sleep Onset Meta-Analysis
claimTemporomandibular disorders (TMDs) are among the most common causes of chronic orofacial pain, with myalgia of the masticatory muscles being a major.Patients frequently present with persistent aching pain, muscle tenderness, and restricted jaw function, all of which significantly impair quality of life.While existing treatments are mainly symptomatic,emerging evidence suggests a role for electrolyte modulation.
evidence level1
citationPatil Shankargouda (2026)
sourceThe Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
topicMagnesium Glycinate Sleep Onset Meta-Analysis
claimNotably, a recent randomized controlled trial demonstrated that local magnesium sulphate injection into the masseter muscle significantly reduced pain intensity and improved function in TMD myalgia, providing a direct clinical link between electrolyte biology and orofacial pain.This observation highlights the potential for broader exploration of electrolyte-based interventions in TMD.
evidence level1
citationPatil Shankargouda (2026)
sourceThe Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
topicMagnesium Glycinate Sleep Onset Meta-Analysis
claimMuscle cramps – whether idiopathic nocturnal, pregnancy-associated, or exercise-induced – arise from abnormal neuromuscular excitability,impaired ion-channel regulation,and nociceptor sensitization.These same processes are also implicated in TMD myalgia,suggesting that insights from cramp interventions may inform novel strategies for managing orofacial muscle pain.
evidence level1
citationPatil Shankargouda (2026)
sourceThe Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
topicMagnesium Glycinate Sleep Onset Meta-Analysis
claimAssociated symptoms may include nausea, vomiting, photophobia, and phonophobia [].
evidence level3
citationRodriguez Juan Pablo (2025)
sourceMagnesium supplementation for migraine prophylaxis
topicMagnesium Glycinate Sleep Onset Meta-Analysis
claimHormonal shifts during breastfeeding might also affect migraine occurrence, although the evidence is not definitive [].
evidence level3
citationRodriguez Juan Pablo (2025)
sourceMagnesium supplementation for migraine prophylaxis
topicMagnesium Glycinate Sleep Onset Meta-Analysis
claimSimilarly, another systematic review found a 7.7% migraine prevalence in this age group, with girls experiencing migraine more often than boys [].
evidence level3
citationRodriguez Juan Pablo (2025)
sourceMagnesium supplementation for migraine prophylaxis
topicMagnesium Glycinate Sleep Onset Meta-Analysis
claimSecondary headaches are triggered by an existing medical problem, such as issues with blood vessels, tumors, infections, or changes in pressure or volume within the skull.
evidence level3
citationRodriguez Juan Pablo (2025)
sourceMagnesium supplementation for migraine prophylaxis

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Source documents

  1. The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
  2. Magnesium supplementation for migraine prophylaxis