Hyaluronic Acid Skin Hydration Meta-Analysis Evidence Table

Structured evidence table for Hyaluronic Acid Skin Hydration Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Hyaluronic Acid Skin Hydration Meta-AnalysisAs for clinical studies, the intervention increased skin hydration (MD = 2.12, 95% CI [1.02; 3.21]) while decreased TEWL (MD = -0.68, 95% CI [-1.21; -0.16]).1Liang Y (2026)Impact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
Hyaluronic Acid Skin Hydration Meta-AnalysisConclusions Antioxidant-rich whole foods or supplements intake improved overall skin health and skin disorder conditions.1Liang Y (2026)Impact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
Hyaluronic Acid Skin Hydration Meta-AnalysisBackground Antioxidant supplements have been reported to confer benefits for skin health; however, these effects remain inconclusive and lack systematic evaluation.1Liang Y (2026)Impact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
Hyaluronic Acid Skin Hydration Meta-AnalysisMethods This systematic review and meta-analysis assessed the impact of antioxidant-rich whole foods or supplements on various skin health outcomes by compiling data from five databases, including 94 eligible preclinical and clinical studies.1Liang Y (2026)Impact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
Hyaluronic Acid Skin Hydration Meta-AnalysisAQP Inhibition ofChannels and Associated Stress Response T11014 8 9 10 11 NHEKs were pretreated with DFP00173 50–100 μM (DFP, TargetMol, TGM‐, United States), a known AQP3 inhibitor [], or Phloretin 250 μM (Sigma, P7912, Germany), a general AQP inhibitor [,,] for 1 h.4Marquardt Kay (2026)Reviving the Skin From Within: Mechanistic Insights Into a Well‐Tolerated Dermal Filler— CPM ‐ HA20G
Hyaluronic Acid Skin Hydration Meta-AnalysisSamples were then lysed in NP40 lysis buffer and analyzed by western blotting for associated stress responses via pP38/tP38.4Marquardt Kay (2026)Reviving the Skin From Within: Mechanistic Insights Into a Well‐Tolerated Dermal Filler— CPM ‐ HA20G
Hyaluronic Acid Skin Hydration Meta-AnalysisCorneometer hydration analysis showed that both glycerol and CPM&#8208;HA20G significantly increased hydration compared to the average control by an average of 31%&#8201;&#177;&#8201;11% (&#8201;<&#8201;0.001) and 10%&#8201;&#177;&#8201;11% (&#8201;<&#8201;0.05), respectively (Figure&#160;).4Marquardt Kay (2026)Reviving the Skin From Within: Mechanistic Insights Into a Well&#8208;Tolerated Dermal Filler&#8212; CPM &#8208; HA20G
Hyaluronic Acid Skin Hydration Meta-AnalysisAQP CPM HA HU IHC NHEKs NMF ROS SC SHE TEWL &#956;CT 1 1 Skin quality is a foundational element of facial attractiveness and a primary motivator for seeking aesthetic treatments.4Marquardt Kay (2026)Reviving the Skin From Within: Mechanistic Insights Into a Well&#8208;Tolerated Dermal Filler&#8212; CPM &#8208; HA20G
topicHyaluronic Acid Skin Hydration Meta-Analysis
claimAs for clinical studies, the intervention increased skin hydration (MD = 2.12, 95% CI [1.02; 3.21]) while decreased TEWL (MD = -0.68, 95% CI [-1.21; -0.16]).
evidence level1
citationLiang Y (2026)
sourceImpact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
topicHyaluronic Acid Skin Hydration Meta-Analysis
claimConclusions Antioxidant-rich whole foods or supplements intake improved overall skin health and skin disorder conditions.
evidence level1
citationLiang Y (2026)
sourceImpact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
topicHyaluronic Acid Skin Hydration Meta-Analysis
claimBackground Antioxidant supplements have been reported to confer benefits for skin health; however, these effects remain inconclusive and lack systematic evaluation.
evidence level1
citationLiang Y (2026)
sourceImpact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
topicHyaluronic Acid Skin Hydration Meta-Analysis
claimMethods This systematic review and meta-analysis assessed the impact of antioxidant-rich whole foods or supplements on various skin health outcomes by compiling data from five databases, including 94 eligible preclinical and clinical studies.
evidence level1
citationLiang Y (2026)
sourceImpact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
topicHyaluronic Acid Skin Hydration Meta-Analysis
claimAQP Inhibition ofChannels and Associated Stress Response T11014 8 9 10 11 NHEKs were pretreated with DFP00173 50&#8211;100&#8201;&#956;M (DFP, TargetMol, TGM&#8208;, United States), a known AQP3 inhibitor [], or Phloretin 250&#8201;&#956;M (Sigma, P7912, Germany), a general AQP inhibitor [,,] for 1&#8201;h.
evidence level4
citationMarquardt Kay (2026)
sourceReviving the Skin From Within: Mechanistic Insights Into a Well&#8208;Tolerated Dermal Filler&#8212; CPM &#8208; HA20G
topicHyaluronic Acid Skin Hydration Meta-Analysis
claimSamples were then lysed in NP40 lysis buffer and analyzed by western blotting for associated stress responses via pP38/tP38.
evidence level4
citationMarquardt Kay (2026)
sourceReviving the Skin From Within: Mechanistic Insights Into a Well&#8208;Tolerated Dermal Filler&#8212; CPM &#8208; HA20G
topicHyaluronic Acid Skin Hydration Meta-Analysis
claimCorneometer hydration analysis showed that both glycerol and CPM&#8208;HA20G significantly increased hydration compared to the average control by an average of 31%&#8201;&#177;&#8201;11% (&#8201;<&#8201;0.001) and 10%&#8201;&#177;&#8201;11% (&#8201;<&#8201;0.05), respectively (Figure&#160;).
evidence level4
citationMarquardt Kay (2026)
sourceReviving the Skin From Within: Mechanistic Insights Into a Well&#8208;Tolerated Dermal Filler&#8212; CPM &#8208; HA20G
topicHyaluronic Acid Skin Hydration Meta-Analysis
claimAQP CPM HA HU IHC NHEKs NMF ROS SC SHE TEWL &#956;CT 1 1 Skin quality is a foundational element of facial attractiveness and a primary motivator for seeking aesthetic treatments.
evidence level4
citationMarquardt Kay (2026)
sourceReviving the Skin From Within: Mechanistic Insights Into a Well&#8208;Tolerated Dermal Filler&#8212; CPM &#8208; HA20G

Source documents

  1. Impact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.
  2. Reviving the Skin From Within: Mechanistic Insights Into a Well&#8208;Tolerated Dermal Filler&#8212; CPM &#8208; HA20G