topicHyaluronic Acid Joint Pain Randomized Trial
claimConclusion Ultrasound-guided hyaluronic acid injection and supervised rehabilitation produced comparable and clinically meaningful improvements in pain, function, and shoulder mobility in frozen-phase adhesive capsulitis.
evidence level2
citationChang CY (2026)
sourceEfficacy of ultrasound-guided intra-articular hyaluronic acid injection in the management of adhesive capsulitis: a randomized controlled trial.
topicHyaluronic Acid Joint Pain Randomized Trial
claimObjective To compare the efficacy and safety of ultrasound-guided intra-articular hyaluronic acid injection versus supervised rehabilitation in patients with frozen-phase adhesive capsulitis.
evidence level2
citationChang CY (2026)
sourceEfficacy of ultrasound-guided intra-articular hyaluronic acid injection in the management of adhesive capsulitis: a randomized controlled trial.
topicHyaluronic Acid Joint Pain Randomized Trial
claimDesign Single-center, parallel-group, randomized controlled trial with 26-week follow-up.
evidence level2
citationChang CY (2026)
sourceEfficacy of ultrasound-guided intra-articular hyaluronic acid injection in the management of adhesive capsulitis: a randomized controlled trial.
topicHyaluronic Acid Joint Pain Randomized Trial
claim1 2 3 4 5 Osteoarthritis (OA) is a degenerative disease characterized by the progressive degeneration of articular cartilage, the development of osteophytes, alterations in subchondral bone and synovial hyperplasia, clinically responsible for increasing disability and reduced quality of life [].
evidence level2
citationRiglet Louis (2026)
sourceEfficacy and safety of a combination of platelet-rich plasma with non-crosslinked hyaluronic acid versus a crosslinked hyaluronic acid, in single-injection for knee osteoarthritis. Randomized, controlled, multicenter, non-inferiority trial
topicHyaluronic Acid Joint Pain Randomized Trial
claimIn vitro studies also suggest improved stimulation of chondrogenesis, and a reduction in both inflammation and chondrocyte catabolism [,].
evidence level2
citationRiglet Louis (2026)
sourceEfficacy and safety of a combination of platelet-rich plasma with non-crosslinked hyaluronic acid versus a crosslinked hyaluronic acid, in single-injection for knee osteoarthritis. Randomized, controlled, multicenter, non-inferiority trial
topicHyaluronic Acid Joint Pain Randomized Trial
claim[] have shown that the release of growth factors is increased in vitro on the fifth day following the addition of HA, which remains to be confirmed clinically.
evidence level2
citationRiglet Louis (2026)
sourceEfficacy and safety of a combination of platelet-rich plasma with non-crosslinked hyaluronic acid versus a crosslinked hyaluronic acid, in single-injection for knee osteoarthritis. Randomized, controlled, multicenter, non-inferiority trial
topicHyaluronic Acid Joint Pain Randomized Trial
claimKnee OA is characterized by multiple symptoms such as mechanical pain, stiffness and disabling inflammatory flare-ups that can reduce locomotor autonomy and promote falls [,].
evidence level2
citationRiglet Louis (2026)
sourceEfficacy and safety of a combination of platelet-rich plasma with non-crosslinked hyaluronic acid versus a crosslinked hyaluronic acid, in single-injection for knee osteoarthritis. Randomized, controlled, multicenter, non-inferiority trial