evidence table

Hyaluronic Acid Joint Comfort Randomized Trial Evidence Table

Name: Hyaluronic Acid Joint Comfort Randomized Trial Evidence Table
Creator: Migaku
License: https://creativecommons.org/licenses/by/4.0/

Structured evidence table for Hyaluronic Acid Joint Comfort Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Hyaluronic Acid Joint Comfort Randomized Trial	In the United States, starting in 2004, it has been employed for the management of facial atrophy in HIV patients.PLLA has been effectively utilized in cases of facial atrophy deformity associated with Parry-Romberg syndrome and connective tissue disease.Since 2009, PLLA has received approval for cosmetic treatment in immunocompetent patients to address nasolabial folds, the midface, and other related areas.	2	Chang Guojing (2026)	Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study
Hyaluronic Acid Joint Comfort Randomized Trial	None of the participants experienced any visual impairment events, and no clinically significant abnormalities in vital signs or laboratory tests associated with PLLA treatment were observed at baseline or during any of the follow-up visits.	2	Chang Guojing (2026)	Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study
Hyaluronic Acid Joint Comfort Randomized Trial	The incidence of blindness associated with PLLA injection was significantly lower compared to that associated with HA.Among the 5 reported cases of PLLA-associated blindness, 1 case was attributed to temporal augmentation.	2	Chang Guojing (2026)	Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study
Hyaluronic Acid Joint Comfort Randomized Trial	5 6 7 , 8-13 Poly-L-Lactic Acid (PLLA) belongs to the polylactic acid (PLA) group.	2	Chang Guojing (2026)	Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study
Hyaluronic Acid Joint Comfort Randomized Trial	The majority of the literature suggests that IAHA has a positive safety profile despite a few meta-analyses suggesting an increased risk of serious adverse effects.	2	Fuggle N (2026)	Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach.
Hyaluronic Acid Joint Comfort Randomized Trial	Specific to IAHA, patients seek minimally invasive, lower-risk, and non-steroidal options with at least moderate efficacy and advantageous safety profiles.	2	Fuggle N (2026)	Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach.
Hyaluronic Acid Joint Comfort Randomized Trial	Hyaluronic acid (HA) is a linear polysaccharide which occurs naturally as a constituent of synovial fluid.	2	Fuggle N (2026)	Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach.
Hyaluronic Acid Joint Comfort Randomized Trial	The HA concentration in the joint decreases inexorably during the progression of knee osteoarthritis (OA) and so, for nearly five decades, HA has been trialled and used in the treatment of knee OA.	2	Fuggle N (2026)	Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach.