topicChlorogenic Acid Blood Glucose Meta-Analysis
claimMMC administration in a rat model of type 2 diabetes mellitus (T2DM) significantly reduced blood glucose, insulin, and lipid levels.
evidence level3
citationChen Jia (2026)
sourceNew directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy
topicChlorogenic Acid Blood Glucose Meta-Analysis
claimInfographic showing mulberry leaf mechanisms for controlling blood glucose: delayed glucose absorption in the small intestine, maintained insulin secretion in the pancreas, enhanced insulin sensitivity in peripheral tissues, and reduced hepatic glucose output with increased glycogen synthesis in the liver.
evidence level3
citationChen Jia (2026)
sourceNew directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy
topicChlorogenic Acid Blood Glucose Meta-Analysis
claimAt the heart of this mechanism lies 1-DNJ, a unique alkaloid found in ML, which interferes with the intestinal step of the final digestion of carbohydrates by means of “competitive inhibition.” The 1-DNJ primarily inhibits two types of key digestive enzymes: α-glucosidase and α-amylase ().
evidence level3
citationChen Jia (2026)
sourceNew directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy
topicChlorogenic Acid Blood Glucose Meta-Analysis
claim1 2 3 4 Diabetes mellitus (DM) is a common metabolic disease, the incidence of which is rapidly increasing worldwide and has become one of the major public health problems threatening human health ().
evidence level3
citationChen Jia (2026)
sourceNew directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy
topicChlorogenic Acid Blood Glucose Meta-Analysis
claimBackground This study aimed to test the hypothesis that a whole Coffea arabica coffee cherry extract concentrated in caffeine and polyphenols would increase exercise performance and muscle glycogen resynthesis.
evidence level4
citationPavis GF (2026)
sourceAn extract from whole <i>Coffea arabica</i> coffee cherry improves time trial performance, but not muscle glycogen resynthesis, in trained cyclists.
topicChlorogenic Acid Blood Glucose Meta-Analysis
claimMethods Twelve trained cyclists (11 male, 1 female; V̇O 2max : 55 ± 2 mL·kg -1 ·min -1 ) took part in a double blind, randomized, placebo-controlled, cross-over trial.
evidence level4
citationPavis GF (2026)
sourceAn extract from whole <i>Coffea arabica</i> coffee cherry improves time trial performance, but not muscle glycogen resynthesis, in trained cyclists.