What does the evidence say about Sulforaphane Oxidative Stress Randomized Trial?

Updated October 2026

Quick Answer

Sulforaphane Oxidative Stress Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: In whole blood, Kelch-like ECH-associating protein 1 (KEAP1) and catalase (CAT) mRNA levels were significantly reduced in iSLE and qSLE.

Key Takeaways

  • 01In whole blood, Kelch-like ECH-associating protein 1 (KEAP1) and catalase (CAT) mRNA levels were significantly reduced in iSLE and qSLE. [Liu L (2026)]
  • 02In conclusion, in qSLE patients, oxidative stress is elevated, while antioxidant capacity is decreased. [Liu L (2026)]
  • 03To elucidate whether it is already present in early phases, we investigate oxidative stress-related genes in incomplete SLE (iSLE) and quiescent SLE (qSLE, inactive disease), as well as the effect of nuclear factor erythroid-derived 2-like 2 (NRF2) activators on NRF2-related genes in peripheral blood mononuclear cells (PBMCs) and HaCaT keratinocytes. [Liu L (2026)]
  • 04In total, 28 qSLE patients, 29 iSLE patients and 21 age- and sex-matched healthy controls (HCs) were included. [Liu L (2026)]
The current Migaku evidence database contains 2 reusable source documents for Sulforaphane Oxidative Stress Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - In whole blood, Kelch-like ECH-associating protein 1 (KEAP1) and catalase (CAT) mRNA levels were significantly reduced in iSLE and qSLE. [Liu L (2026); evidence level 4] - In conclusion, in qSLE patients, oxidative stress is elevated, while antioxidant capacity is decreased. [Liu L (2026); evidence level 4] - To elucidate whether it is already present in early phases, we investigate oxidative stress-related genes in incomplete SLE (iSLE) and quiescent SLE (qSLE, inactive disease), as well as the effect of nuclear factor erythroid-derived 2-like 2 (NRF2) activators on NRF2-related genes in peripheral blood mononuclear cells (PBMCs) and HaCaT keratinocytes. [Liu L (2026); evidence level 4] - In total, 28 qSLE patients, 29 iSLE patients and 21 age- and sex-matched healthy controls (HCs) were included. [Liu L (2026); evidence level 4] - Sulforaphane Mitigates Oxidative Stress in Alzheimer's Disease (AD) through NRF2 Activation [Khan Wasi Uzzaman (2025); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Oxidative Stress and NRF2-Mediated Redox Regulation in Incomplete Systemic Lupus Erythematosus and Systemic Lupus Erythematosus.
  2. Sulforaphane Mitigates Oxidative Stress in Alzheimer's Disease (AD) through NRF2 Activation