topicSulforaphane Oxidative Stress Randomized Trial
claimIn whole blood, Kelch-like ECH-associating protein 1 (KEAP1) and catalase (CAT) mRNA levels were significantly reduced in iSLE and qSLE.
evidence level4
citationLiu L (2026)
sourceOxidative Stress and NRF2-Mediated Redox Regulation in Incomplete Systemic Lupus Erythematosus and Systemic Lupus Erythematosus.
topicSulforaphane Oxidative Stress Randomized Trial
claimIn conclusion, in qSLE patients, oxidative stress is elevated, while antioxidant capacity is decreased.
evidence level4
citationLiu L (2026)
sourceOxidative Stress and NRF2-Mediated Redox Regulation in Incomplete Systemic Lupus Erythematosus and Systemic Lupus Erythematosus.
topicSulforaphane Oxidative Stress Randomized Trial
claimTo elucidate whether it is already present in early phases, we investigate oxidative stress-related genes in incomplete SLE (iSLE) and quiescent SLE (qSLE, inactive disease), as well as the effect of nuclear factor erythroid-derived 2-like 2 (NRF2) activators on NRF2-related genes in peripheral blood mononuclear cells (PBMCs) and HaCaT keratinocytes.
evidence level4
citationLiu L (2026)
sourceOxidative Stress and NRF2-Mediated Redox Regulation in Incomplete Systemic Lupus Erythematosus and Systemic Lupus Erythematosus.
topicSulforaphane Oxidative Stress Randomized Trial
claimIn total, 28 qSLE patients, 29 iSLE patients and 21 age- and sex-matched healthy controls (HCs) were included.
evidence level4
citationLiu L (2026)
sourceOxidative Stress and NRF2-Mediated Redox Regulation in Incomplete Systemic Lupus Erythematosus and Systemic Lupus Erythematosus.
topicSulforaphane Oxidative Stress Randomized Trial
claimSulforaphane Mitigates Oxidative Stress in Alzheimer's Disease (AD) through NRF2 Activation
evidence level4
citationKhan Wasi Uzzaman (2025)
sourceSulforaphane Mitigates Oxidative Stress in Alzheimer's Disease (AD) through NRF2 Activation