topicGlutathione Oxidative Stress Randomized Trial
claimResults Induction of endometriosis significantly reduced serum 2-arachidonoylglycerol, anandamide, superoxide dismutase, and glutathione levels while increasing malondialdehyde concentrations compared with the Sham group (p Conclusion Bromelain ameliorated endocannabinoid deficiency and oxidative stress in experimental endometriosis.
evidence level4
citationHerguner I (2026)
sourceEffects of bromelain on endocannabinoid system and oxidative stress in a rat model of endometriosis.
topicGlutathione Oxidative Stress Randomized Trial
claimObjective The objective of this study is to evaluate the effects of bromelain on serum endocannabinoid levels and oxidative stress markers in a rat model of surgically induced endometriosis.
evidence level4
citationHerguner I (2026)
sourceEffects of bromelain on endocannabinoid system and oxidative stress in a rat model of endometriosis.
topicGlutathione Oxidative Stress Randomized Trial
claimMethods A total of 24 female Wistar albino rats were randomly assigned to three groups (n=8 each): Sham, endometriosis, and endometriosis treated with bromelain (endometriosis+B).
evidence level4
citationHerguner I (2026)
sourceEffects of bromelain on endocannabinoid system and oxidative stress in a rat model of endometriosis.
topicGlutathione Oxidative Stress Randomized Trial
claimObesity is a chronic metabolic disorder characterized by excessive adipose tissue accumulation and associated with systemic oxidative stress, mitochondrial dysfunction, and chronic low-grade inflammation.
evidence level4
citationWang R (2026)
sourceMolecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies.
topicGlutathione Oxidative Stress Randomized Trial
claimAdipose tissue dysfunction promotes the overproduction of reactive oxygen species through multiple mechanisms, including NADPH oxidase activation, mitochondrial electron transport chain leakage, and endoplasmic reticulum stress via mitochondria-associated ER membranes.
evidence level4
citationWang R (2026)
sourceMolecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies.
topicGlutathione Oxidative Stress Randomized Trial
claimMoreover, obesity impairs endogenous antioxidant defense systems, including reduced activity of superoxide dismutase, glutathione peroxidase, and catalase, as well as magnesium deficiency that compromises glutathione synthesis.
evidence level4
citationWang R (2026)
sourceMolecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies.