stress mood

Saffron Mood Stress Randomized Trial Evidence Table

Structured evidence table for Saffron Mood Stress Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Saffron Mood Stress Randomized TrialSaffron was also associated with greater improvements in self-esteem (adjusted mean difference: 1.43; 95% CI: 0.22, 2.64; d = 0.51; p = 0.022) and sleep-related impairment (adjusted mean difference: 2.99; 95% CI: 0.12, 5.86; d = 0.45; p = 0.041).2Lopresti AL (2026)The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
Saffron Mood Stress Randomized TrialConclusion Supplementation with a saffron extract (Affron®) for 12 weeks was associated with improvements in depressive symptoms.2Lopresti AL (2026)The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
Saffron Mood Stress Randomized TrialBackground Depression is commonly accompanied by sleep disturbances and low self-esteem.2Lopresti AL (2026)The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
Saffron Mood Stress Randomized TrialSaffron ( Crocus sativus L.) has demonstrated antidepressant and sleep-enhancing effects in previous clinical trials; however, its efficacy in women experiencing both low mood and poor sleep has not been specifically examined.2Lopresti AL (2026)The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
Saffron Mood Stress Randomized TrialBehavioral analysis revealed that cold stress significantly impaired memory and increased anxiety-like behavior, whereas oral supplementation of saffron extract reduced anxiety, improved spontaneous alternation and enhanced object recognition memory.4Priya V (2026)<i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.
Saffron Mood Stress Randomized TrialConclusion Saffron extract enhances neurobehavioral functions, significantly ameliorating cold stress-induced cognitive deficits and anxiety-like behavior.4Priya V (2026)<i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.
Saffron Mood Stress Randomized TrialIntroduction Chronic cold stress acts as an influential environmental stressor that disrupts neuro-behavioral functions, which include anxiety responses, cognitive performance, mood regulation, and stress susceptibility.4Priya V (2026)<i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.
Saffron Mood Stress Randomized TrialIn spite of the growing recognition of cold-induced neuropathology, effective therapeutic strategies remain limited.4Priya V (2026)<i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.
topicSaffron Mood Stress Randomized Trial
claimSaffron was also associated with greater improvements in self-esteem (adjusted mean difference: 1.43; 95% CI: 0.22, 2.64; d = 0.51; p = 0.022) and sleep-related impairment (adjusted mean difference: 2.99; 95% CI: 0.12, 5.86; d = 0.45; p = 0.041).
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Mood Stress Randomized Trial
claimConclusion Supplementation with a saffron extract (Affron®) for 12 weeks was associated with improvements in depressive symptoms.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Mood Stress Randomized Trial
claimBackground Depression is commonly accompanied by sleep disturbances and low self-esteem.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Mood Stress Randomized Trial
claimSaffron ( Crocus sativus L.) has demonstrated antidepressant and sleep-enhancing effects in previous clinical trials; however, its efficacy in women experiencing both low mood and poor sleep has not been specifically examined.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Mood Stress Randomized Trial
claimBehavioral analysis revealed that cold stress significantly impaired memory and increased anxiety-like behavior, whereas oral supplementation of saffron extract reduced anxiety, improved spontaneous alternation and enhanced object recognition memory.
evidence level4
citationPriya V (2026)
source<i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.
topicSaffron Mood Stress Randomized Trial
claimConclusion Saffron extract enhances neurobehavioral functions, significantly ameliorating cold stress-induced cognitive deficits and anxiety-like behavior.
evidence level4
citationPriya V (2026)
source<i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.
topicSaffron Mood Stress Randomized Trial
claimIntroduction Chronic cold stress acts as an influential environmental stressor that disrupts neuro-behavioral functions, which include anxiety responses, cognitive performance, mood regulation, and stress susceptibility.
evidence level4
citationPriya V (2026)
source<i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.
topicSaffron Mood Stress Randomized Trial
claimIn spite of the growing recognition of cold-induced neuropathology, effective therapeutic strategies remain limited.
evidence level4
citationPriya V (2026)
source<i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.

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Source documents

  1. The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
  2. <i>Crocus sativus</i> improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress.