What does the evidence say about Soy Isoflavones Skin Hydration Randomized Trial?

The current Migaku evidence database contains 2 reusable source documents for Soy Isoflavones Skin Hydration Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - The aim of this study is to expand upon existing evidence of the benefits of soy isoflavones in postmenopausal women with Fitzpatrick skin types I&#8211;IV, by examining the effects of a 12-week supplementation period on parameters of skin health and determining whether these effects are S-equol dependent. [Vijayakumar Vineetha (2025); evidence level 2] - These analyses were performed in R v4.3.3, using thefunction for backward stepwise variable selection to remove unnecessary predictors, using AIC criteria ().-values of the linear regressions were corrected following Benjamini-Hochberg procedure to reduce the risk of type I errors. [Vijayakumar Vineetha (2025); evidence level 2] - p&#8239;< &#8211; p&#8239;< p&#8239;< p&#8239;< n&#8239;= p&#8239;= Figures 4B E Figure 4B Supplementary Table 2 Figures 4C D Supplementary Table 2 Figure 4E Supplementary Table 2 In addition, supplementation with Novasoy&#174;400 significantly increased the concentration of all four metabolites from D0 to D84, as determined by the Wilcoxon test (&#8239;0.05) (). [Vijayakumar Vineetha (2025); evidence level 2] - 1 2 3 4 Menopause triggers a decline in oestrogen levels, causing various physiological alterations, including accelerated skin aging (). [Vijayakumar Vineetha (2025); evidence level 2] - Preliminary findings from multiple studies indicate that dietary intake of soy-derived isoflavones exert beneficial effects on the skin including defense against oxidant damage, stimulation of collagen synthesis, and increased hydration. [Rizzo J (2023); evidence level 2] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.