topicSoy Isoflavones Skin Health Meta-Analysis
claimThe aim of this study is to expand upon existing evidence of the benefits of soy isoflavones in postmenopausal women with Fitzpatrick skin types I–IV, by examining the effects of a 12-week supplementation period on parameters of skin health and determining whether these effects are S-equol dependent.
evidence level2
citationVijayakumar Vineetha (2025)
sourceS-equol status modulates skin response to soy isoflavones in postmenopausal women: results from a randomized placebo-controlled pilot trial
topicSoy Isoflavones Skin Health Meta-Analysis
claimThese analyses were performed in R v4.3.3, using thefunction for backward stepwise variable selection to remove unnecessary predictors, using AIC criteria ().-values of the linear regressions were corrected following Benjamini-Hochberg procedure to reduce the risk of type I errors.
evidence level2
citationVijayakumar Vineetha (2025)
sourceS-equol status modulates skin response to soy isoflavones in postmenopausal women: results from a randomized placebo-controlled pilot trial
topicSoy Isoflavones Skin Health Meta-Analysis
claimp < – p < p < p < n = p = Figures 4B E Figure 4B Supplementary Table 2 Figures 4C D Supplementary Table 2 Figure 4E Supplementary Table 2 In addition, supplementation with Novasoy®400 significantly increased the concentration of all four metabolites from D0 to D84, as determined by the Wilcoxon test ( 0.05) ().
evidence level2
citationVijayakumar Vineetha (2025)
sourceS-equol status modulates skin response to soy isoflavones in postmenopausal women: results from a randomized placebo-controlled pilot trial
topicSoy Isoflavones Skin Health Meta-Analysis
claim1 2 3 4 Menopause triggers a decline in oestrogen levels, causing various physiological alterations, including accelerated skin aging ().
evidence level2
citationVijayakumar Vineetha (2025)
sourceS-equol status modulates skin response to soy isoflavones in postmenopausal women: results from a randomized placebo-controlled pilot trial
topicSoy Isoflavones Skin Health Meta-Analysis
claimThey have been found in numerous plant species belonging to the Leguminosae family, including soy (), kudzu (), and red clover ().
evidence level4
citationWójciak Magdalena (2024)
sourceProtective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies
topicSoy Isoflavones Skin Health Meta-Analysis
claimIsoflavones are found mostly in the aerial parts of the plant, with the greatest abundance in the seeds [].
evidence level4
citationWójciak Magdalena (2024)
sourceProtective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies
topicSoy Isoflavones Skin Health Meta-Analysis
claimStudies have shown that they exhibit multidirectional biological activity, helping to prevent obesity [], lower blood glucose levels [], and reduce the risk of osteoporosis [], certain types of cancer [], and metabolic-related cardiovascular disorders [].
evidence level4
citationWójciak Magdalena (2024)
sourceProtective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies
topicSoy Isoflavones Skin Health Meta-Analysis
claimFigure 1 1 2 3 4 5 6 7 Figure 1 8 Glycine max Pueraria lobata Trifolium pratense Isoflavones belong to polyphenolic compounds and are distinguished from the flavonoid class based on the characteristic location of the second benzene ring attached to the heterocyclic pyran.
evidence level4
citationWójciak Magdalena (2024)
sourceProtective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies